Anti-PHF2 Antibody

Name: Anti-PHF2 Antibody
Brand: PhosphoSolutions
SKU: 24120
Price: 456.0 USD
Availability: InStock

Our PHF2 rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human PHF2 and is antigen affinity purified. It is great for use in WB.

Western Blot of placenta lysate showing specific immunolabeling of PHF2.

Click on image to zoom

Species Reactivity

Human

Applications

ELISA, WB

Host Species

Rabbit

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Data Sheet

SKU: 24120

Title: 100 µL

Variant

Price:

$456.00

Quantity:

Ships: 1-2 business days

Product Details

Target

PHF2

Scientific Background

PHF-2 is widely expressed and is implicated in hereditary sensory neuropathy type 1 HSN1.

Format

Antigen Affinity Purified

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, WB

Host Species

Rabbit

Gene Name

PHF2

Immunogen

Synthetic peptide corresponding to residues from an internal region of the 120 kDa PHF protein

Immunogen Species

Human

Species Reactivity

Human

Storage

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

Physical State

Liquid

Buffer

PBS + 0.02% NaN3

Dilution Ranges

WB: 1:500-1:1000
WB Brain: 1:500-1:1000

Specificity

Reacts with residues from an internal region of the 120 kDa PHF protein.

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Country of Origin

United States

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Synonyms

CENP-35; GRC5; JHDM1E; KDM7C; lysine-specific demethylase PHF2; centromere protein 35; jumonji C domain-containing histone demethylase 1E; PHD finger protein 2; Jumonji C domain containing histone demethylase 1E

UniProt ID

O75151
UniProt Summary: Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA. Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters.

NCBI Gene ID

5253

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Anti-PHF2 Antibody

SKU: 24120

Product Details

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