Anti-NSE2 Antibody

Name: Anti-NSE2 Antibody
Brand: PhosphoSolutions
SKU: 24351
Price: 456.0 USD
Availability: InStock

Our E3 SUMO-protein ligase NSE2 rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human E3 SUMO-protein ligase NSE2 and is antigen affinity purified. It is great for use in WB.

Species Reactivity

Human

Applications

ELISA, WB

Host Species

Rabbit

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Data Sheet

SKU: 24351

Title: 100 µL

Variant

Price:

$456.00

Quantity:

Ships: 1-2 business days

Product Details

Target

E3 SUMO-protein ligase NSE2

Scientific Background

The structural maintenance of chromosomes (SMC) family of proteins play essential roles in genomic stability. Nse1 and Nse2 are essential proteins and conserved from yeast to man and loss of function leads to similar terminal phenotypes to those observed for Smc5-6 inactivation. Data suggests that like Smc5-6, Nse1, and Nse2 function in the homologous recombination repair of DNA double strand breaks.

Format

Antigen Affinity Purified

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, WB

Host Species

Rabbit

Gene Name

NSMCE2

Immunogen

Synthetic peptide corresponding to amino acids from the C-terminal region of human NSE2.

Immunogen Species

Human

Species Reactivity

Human

Storage

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

Physical State

Liquid

Buffer

PBS + 0.02% NaN3

Dilution Ranges

WB: 1:500-1:1000
WB Brain: 1:500-1:1000

Specificity

Reacts with the C-terminal region of human Nse2

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Country of Origin

United States

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Synonyms

C8orf36; E3 SUMO-protein ligase NSE2; NSE2; ZMIZ7; E3 SUMO-protein transferase NSE2; NSMCE2/PVT1 fusion; PVT1/NSMCE2 fusion; methyl methanesulfonate sensitivity gene 21; non-SMC element 2; MMS21 homolog; zinc finger; MIZ-type containing 7; NSMCE2; Non-structural maintenance of chromosomes element 2 homolog; MMS21

UniProt ID

Q96MF7
UniProt Summary: E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TSNAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, RAD51AP1, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repair, and for formation of APBs in ALT cell lines. Required for sister chromatid cohesion during prometaphase and mitotic progression.

NCBI Gene ID

286053

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Anti-NSE2 Antibody

SKU: 24351

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