Anti-Noxa Antibody

Name: Anti-Noxa Antibody
Brand: Biosensis
SKU: R-124-100
Price: 337.0 USD
Availability: InStock

Our Anti-Noxa rabbit polyclonal primary antibody detects mouse Noxa, and is whole serum. It is validated for use in WB.

Anti-Noxa Antibody

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Species Reactivity

Mouse

Applications

Host Species

Rabbit

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Data Sheet

SKU: R-124-100

Volume/Size: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Noxa

Scientific Background

The Bcl-2 family of proteins which regulate apoptosis share identical sequences called Bcl-2 Homology domains (BH1-4). The BH3 proteins, including BID, NOXA, PUMA, BIK, BIM and BAD are all pro-apoptotic and share sequence identity within the amphipathic alpha-helical BH3 region, which is essential for their apoptotic function. NOXA is highly expressed in adult T-cell leukemia cell line.

Format

Whole serum

Clonality

Polyclonal

Isotype

Mixed

Applications

Host Species

Rabbit

Immunogen

A synthetic peptide (CAQLRR IGDKVNLRQK) as part of mouse Noxa (aa: 75-90) conjugated to diphtheria toxoid

Immunogen Species

Mouse

Species Reactivity

Mouse

Storage

Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

Physical State

Lyophilized

Dilution Ranges

WB: 1:1000-1:2000

Conjugate

Unconjugated

Specificity

Western blot analysis of cells infected with Noxa adenoviruses and BAF indicates a high level of specificity for this antiserum. This antiserum cross-reacts with mouse. Not yet tested in other species.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

Noxa; PMAIP1; protein Noxa; phorbol-12-myristate-13-acetate-induced protein 1; adult T cell leukemia-derived PMA-responsive; Immediate-early-response protein APR; PMA-induced protein 1

UniProt ID

Q9JM54
UniProt Summary: Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1. Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.

NCBI Gene ID

58801

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25°C (ambient)

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Anti-Noxa Antibody

SKU: R-124-100

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