Anti-Nanog Antibody

Name: Anti-Nanog Antibody
Brand: PhosphoSolutions
SKU: 37134
Price: 456.0 USD
Availability: InStock

Our Nanog rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human Nanog and is antigen affinity purified. It is great for use in WB.

Species Reactivity

Human

Applications

ELISA, WB

Host Species

Rabbit

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Data Sheet

SKU: 37134

Title: 100 µL

Variant

Price:

$456.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Nanog

Scientific Background

The transcriptional factor Nanog functions in maintaining pluripotency in cooperation with other key genes such as Oct4. Oct4 and Sox2 bind to the Nanog promoter in mouse and human embryonic stem cell. Nanog levels allow stem cells to balance the creation of lineage-committed and undifferentiated cells.

Format

Antigen Affinity Purified

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, WB

Host Species

Rabbit

Gene Name

NANOG

Immunogen

Synthetic peptide corresponding to an internal sequence of the human Nanog protein.

Immunogen Species

Human

Species Reactivity

Human

Storage

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

Physical State

Liquid

Buffer

PBS + 0.02% NaN3

Dilution Ranges

WB: 1:500-1:1000
WB Brain: 1:500-1:1000

Specificity

Reacts with an internal sequence of the human nanog protein

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Country of Origin

United States

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Synonyms

Embryonic stem cell specific homeobox protein; ENK; Nanog ; Alternative names; ENK ; Alternative names; FLJ12581 ; Embryonic stem cell specific homeobox protein; hNanog ; Homeobox protein NANOG ; Homeobox transcription factor Nanog ; homeobox transcription factor Nanog-delta 48

UniProt ID

Q9H9S0
UniProt Summary: Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Binds to the POU5F1/OCT4 promoter. Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation.

NCBI Gene ID

79923

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Anti-Nanog Antibody

SKU: 37134

Product Details

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