Anti-IKAP (N-terminal) Antibody

Name: Anti-IKAP (N-terminal) Antibody
Brand: PhosphoSolutions
SKU: 24163
Price: 456.0 USD
Availability: InStock

Our IKAP rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human IKAP and is antigen affinity purified. It is great for use in WB.

Western Blot of Interleukin-1-stimulated 293 cells showing specific immunolabeling of IKAP.

Click on image to zoom

Species Reactivity

Human

Applications

ELISA, WB

Host Species

Rabbit

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Data Sheet

SKU: 24163

Title: 100 µL

Variant

Price:

$456.00

Quantity:

Ships: 1-2 business days

Product Details

Target

IKAP

Scientific Background

The transcription factor NF-kappaB coordinates the activation of numerous genes in response to pathogens and pro-inflammatory cytokines, and is, therefore, vital in the development of acute and chronic inflammatory diseases. NF-kappaB is activated by cytokine-activated IKB kinases (IKKs); IKK-alpha and IKK-beta isozymes are found in large complexes These large, interleukin-1-inducible IKK complexes have been found to contain a new protein, termed IKK-complex-associated protein (IKAP), which can bind NIK and IKKs and assemble them into an active kinase complex. IKAP is a scaffold protein and a regulator for three different kinases involved in pro-inflammatory cytokine signaling.

Format

Antigen Affinity Purified

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, WB

Host Species

Rabbit

Gene Name

ELP1

Immunogen

Synthetic peptide corresponding to amino acids from the N-terminal region of human IKAP protein

Immunogen Species

Human

Species Reactivity

Human

Storage

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

Physical State

Liquid

Buffer

PBS + 0.02% NaN3

Dilution Ranges

WB: 1:500-1:1000
WB Brain: 1:500-1:1000

Specificity

Reacts with the N-terminus of human IKAP protein. Sequence is 92% identical to rat and 85% identical to mouse.

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Country of Origin

United States

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Synonyms

DYS; Elongator complex protein 1; IKAP; IKBKAP; IKI3; TOT1; IKK complex-associated protein; elongator acetyltransferase complex subunit 1; ikappaB kinase complex-associated protein; ELP1; IkappaB kinase complex associated protein; p150

UniProt ID

O95163
UniProt Summary: Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation. ELP1 binds to tRNA, mediating interaction of the elongator complex with tRNA. May act as a scaffold protein that assembles active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK).

NCBI Gene ID

8518

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Anti-IKAP (N-terminal) Antibody

SKU: 24163

Product Details

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