Anti-GABABR1b Antibody

Name: Anti-GABABR1b Antibody
Brand: PhosphoSolutions
SKU: 24147
Price: 456.0 USD
Availability: InStock

Our GABABR1b rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human, mouse, and rat GABABR1b and is antigen affinity purified. It is great for use in WB.

Western Blot of brain lysate showing specific immunolabeling of GABA-B R1.

Click on image to zoom

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, WB

Host Species

Rabbit

Go to Full Product Details

Data Sheet

SKU: 24147

Title: 100 µL

Variant

Price:

$456.00

Quantity:

Ships: 1-2 business days

Product Details

Target

GABABR1b

Scientific Background

The inhibitory neurotransmitter, GABA, acts through two ligand-gated channels, GABAA and GABAC receptors and GABAB, the latter of which acts through a G protein mechanism. GABABR1 is one of the two G-protein coupled receptors for GABAB that acts as a heteromeric assembly with GABABR2.

Format

Antigen Affinity Purified

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, WB

Host Species

Rabbit

Gene Name

GABBR1b

Immunogen

Synthetic peptide corresponding to amino acids from the N-terminal region of human GABABR1b protein

Immunogen Species

Human

Species Reactivity

Human, Mouse, Rat

Storage

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

Physical State

Liquid

Buffer

PBS + 0.02% NaN3

Dilution Ranges

WB: 1:500-1:1000
WB Brain: 1:500-1:1000

Specificity

Reacts with the N-terminal region of human, mouse and rat GABABR1b protein.

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Country of Origin

United States

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Synonyms

dJ271M21.1.1; GABA B receptor 1 b; dJ271M21.1.2; FLJ92613; GABA-B receptor 1; GABA-B-R1; GABA-BR1; GABAB R1; GABAB subunit 1c; GABABR1; GABBR1 3; GABBR1; GABR1_HUMAN; Gamma aminobutyric acid (GABA B receptor 1; Gamma-aminobutyric acid type B receptor subunit 1; Gb1; GPRC3A; Seven transmembrane helix receptor; Gamma aminobutyric acid B receptor 1 b; GABBR1b

UniProt ID

Q9UBS5
UniProt Summary: Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Calcium is required for high affinity binding to GABA. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable). Activated by (-)-baclofen, cgp27492 and blocked by phaclofen.

NCBI Gene ID

2550

Shipping

Blue Ice

Recover password

Create my account

Anti-GABABR1b Antibody

SKU: 24147

Product Details

Bulk Order Anti-GABABR1b Antibody

Related Products

Recently Viewed