Anti-Frizzled 7 (fz7) Antibody

Name: Anti-Frizzled 7 (fz7) Antibody
Brand: PhosphoSolutions
SKU: 24137
Price: 456.0 USD
Availability: InStock

Our Frizzled 7 rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects mouse Frizzled 7 and is antigen affinity purified. It is great for use in WB.

Western Blot of mouse pancreas lysate showing specific immunolabeling of Frizzled-7.

Click on image to zoom

Species Reactivity

Mouse

Applications

ELISA, WB

Host Species

Rabbit

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Data Sheet

SKU: 24137

Title: 100 µL

Variant

Price:

$456.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Frizzled 7

Scientific Background

Frizzled 7 (fz7) is a member of the frizzzled (fz) family, which has been shown to be the transmembrane receptors for the Wnt molecules. Wnts have been implicated in embryonic induction, cell fate determination, control of cell polarity and malignant transformation.

Format

Antigen Affinity Purified

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, WB

Host Species

Rabbit

Gene Name

FZD7

Immunogen

Synthetic peptide corresponding to amino acids from the N-terminal region of mouse Frizzled 7 protein

Immunogen Species

Mouse

Species Reactivity

Mouse

Storage

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

Physical State

Liquid

Buffer

PBS + 0.02% NaN3

Dilution Ranges

WB: 1:500-1:1000
WB Brain: 1:500-1:1000

Specificity

Reacts with the N-terminal region of mouse Frizzled 7 protein

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Country of Origin

United States

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Synonyms

Fz7; frizzled homolog 7; fz-7; mFz7; frizzled class receptor 7; FZD7; FzE3; Homolog of Drosophila Frizzled 7

UniProt ID

Q61090
UniProt Summary: Receptor for Wnt proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. Activation by WNT8 induces expression of beta-catenin target genes. Following ligand activation, binds to CCDC88C/DAPLE which displaces DVL1 from FZD7 and leads to inhibition of canonical Wnt signaling, activation of G-proteins by CCDC88C and triggering of non-canonical Wnt responses. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.

NCBI Gene ID

14369

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Anti-Frizzled 7 (fz7) Antibody

SKU: 24137

Product Details

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