Anti-BRCAA1 Antibody

Name: Anti-BRCAA1 Antibody
Brand: PhosphoSolutions
SKU: 24419
Price: 456.0 USD
Availability: InStock

Our BRCAA1 rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human, mouse, and rat BRCAA1 and is antigen affinity purified. It is great for use in WB.

Western Blot of MCF-7 whole cell lysate (15 ug) showing specific immunolabeling of BRCAA1

Click on image to zoom

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, WB

Host Species

Rabbit

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Data Sheet

SKU: 24419

Title: 100 µL

Variant

Price:

$456.00

Quantity:

Ships: 1-2 business days

Product Details

Target

BRCAA1

Scientific Background

The novel BRCAA1 protein’s epitope was mapped to the cytoplasm of MCF-7 cells. Immunohistochemistry analysis showed that the antigen epitope exhibited positive expression in 65% of breast cancer specimens. Its expression is associated with characteristics that are associated with prognosis of breast cancer, and its sera antibody level may be helpful for breast cancer diagnosis.

Format

Antigen Affinity Purified

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, WB

Host Species

Rabbit

Gene Name

ARID4B

Immunogen

Synthetic peptide corresponding to amino acids from an internal sequence of the humanBRCAA1 protein

Immunogen Species

Human

Species Reactivity

Human, Mouse, Rat

Storage

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

Physical State

Liquid

Buffer

PBS + 0.02% NaN3

Dilution Ranges

WB: 1:500-1:1000
WB Brain: 1:500-1:1000

Specificity

Reacts with an internal region of the 136 kDa human, mouse and rat BRCAA1 protein.

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Country of Origin

United States

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Synonyms

BCAA; AT rich interactive domain 4B; RBBP1L1; RBP1- like isoform 1; RBP1L1; RBP1-like protein; SAP180; breast carcinoma-associated antigen BCAA; AT-rich interactive domain-containing protein 4B; breast cancer-associated antigen BRCAA1; 180 kDa Sin3-associated polypeptide; Rb-binding protein homolog; ARID domain-containing protein 4B; retinoblastoma-binding protein 1-like 1; AT rich interactive domain 4B (RBP1-like; SIN3A-associated protein 180; retinoblastoma binding protein 1-like 1; breast cancer-associated antigen 1; breast carcinoma-associated antigen; histone deacetylase complex subunit SAP180; sin3-associated polypeptide p180; ARID4B

UniProt ID

Q4LE39
UniProt Summary: Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. Plays a role in the regulation of epigenetic modifications at the PWS/AS imprinting center near the SNRPN promoter, where it might function as part of a complex with RB1 and ARID4A. Involved in spermatogenesis, together with ARID4A, where it functions as a transcriptional coactivator for AR (androgen receptor) and enhances expression of genes required for sperm maturation. Regulates expression of the tight junction protein CLDN3 in the testis, which is important for integrity of the blood-testis barrier. Plays a role in myeloid homeostasis where it regulates the histone methylation state of bone marrow cells and expression of various genes involved in hematopoiesis. May function as a leukemia suppressor.

NCBI Gene ID

51742

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Anti-BRCAA1 Antibody

SKU: 24419

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