Anti-Beta Tubulin III (Tuj-1) Antibody

Name: Anti-Beta Tubulin III (Tuj-1) Antibody
Brand: PhosphoSolutions
SKU: 24661
Price: 456.0 USD
Availability: InStock

Our Beta Tubulin III rabbit polyclonal primary antibody from PhosphoSolutions is produced in-house. It detects human, mouse, and rat Beta Tubulin III and is antigen affinity purified. It is great for use in WB.

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, WB

Host Species

Rabbit

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Data Sheet

SKU: 24661

Title: 100 µL

Variant

Price:

$456.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Beta Tubulin III

Scientific Background

The beta-tubulin III protein (also know as Tuj 1) belongs to the tubulin superfamily and is abundant in the brain, where it is expressed almost exclusively in neurons after differentiation. There are significant post-translational modifications made to beta-tubulin III with numerous isoforms present during early post-natal neural development. Altered patterns of expression are noted in brain tumors such as medulloblastomas

Format

Antigen Affinity Purified

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, WB

Host Species

Rabbit

Gene Name

TUBB3

Immunogen

Synthetic peptide corresponding to amino acids from the C-terminal region human beta-tubulin-III protein

Immunogen Species

Human

Species Reactivity

Human, Mouse, Rat

Storage

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

Physical State

Liquid

Buffer

PBS + 0.02% NaN3

Dilution Ranges

WB: 1:500-1:1000
WB Brain: 1:500-1:1000

Specificity

Reacts with C-terminal region of the 50 kDa human beta-tubulin-III protein. 94% sequence identity in mouse and rat.

Quality Control

Western blots performed on each lot.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Country of Origin

United States

Expiration

After date of receipt, stable for at least 1 year at -20°C.

Synonyms

beta 3 tubulin; TUBB3; beta-4; beta III Tubulin; CDCBM; CDCBM1; CFEOM3; CFEOM3A; FEOM3; M(beta3; M(beta6; MC1R; Neuron specific beta III Tubulin; Neuron-specific class III beta-tubulin; QccE-11995; QccE-15186; TBB3_HUMAN; Tubb 3; TUBB3; TUBB4; Tubulin beta 3; Tubulin beta 3 chain; Tubulin beta 4; Tubulin beta III; Tubulin beta-3 chain; Tubulin beta-4 chain; Tubulin beta-III; Tubulin beta-3 chain; Tubulin beta-4 chain; TUBB4

UniProt ID

Q13509
UniProt Summary: Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, alpha-beta tubulin heterodimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. TUBB3 plays a critical role in proper axon guidance and maintenance. Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion. Plays a role in dorsal root ganglion axon projection towards the spinal cord.

NCBI Gene ID

10381

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Anti-Beta Tubulin III (Tuj-1) Antibody

SKU: 24661

Product Details

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