Anti-Beta-synuclein Antibody

Name: Anti-Beta-synuclein Antibody
Brand: Biosensis
SKU: R-1683-500
Price: 347.0 USD
Availability: InStock

Our Anti-Beta-synuclein rabbit polyclonal primary antibody detects human and mouse Beta-synuclein, and is IgG. It is validated for use in IHC-Frozen, WB.

Western Immunoblotting of human b-synuclein protein in human brain homogenate, 10 ug protein per lane. Crude anti-beta-synuclein ab (Catalog Number R-1683-100) used at 1:1000.
Peptide absorption reduced antibody reactivity for expected beta-synuclein band of 17 kDa.

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Species Reactivity

Human, Mouse

Applications

IHC, WB

Host Species

Rabbit

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Data Sheet

SKU: R-1683-500

Volume/Size: 500 µg

Variant

Price:

$347.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Beta-synuclein

Scientific Background

Beta-synuclein is a soluble cytoplasmic protein associated with synaptic vesicles and a member of the synuclein family. Mutations in alpha-synuclein cause early onset Parkinson's disease. Expression of beta synuclein may modulate alpha-synuclein aggregation found in Parkinson's disease.

Format

IgG

Clonality

Polyclonal

Isotype

IgG

Applications

IHC, WB

Host Species

Rabbit

Molecular Weight

17 kDa

Immunogen

A synthetic peptide (AQEAAEEPLIEPLME-C) corresponding to human _-synuclein [99-113] in the C-terminal domain conjugated via additional C-terminal Cys to Diphtheria toxoid.

Immunogen Species

Human

Species Reactivity

Human, Mouse

Storage

Spin vial briefly before opening. Reconstitute in 500 µL sterile-filtered 1X PBS, pH 7.2-7.6. Centrifuge to remove any insoluble material.Lyophilized at 2-8°C. After reconstitution, store at -20°C in undiluted aliquots for up to 6 months. The antibody may be stored short term at 2-2-8°C with an appropriate antibacterial agent. Avoid freeze-thaw cycles.

Physical State

Lyophilized

Production Notes

Protein G purified IgG

Buffer

Lyophilized from PBS, pH 7.4. Contains no preservative.

Dilution Ranges

WB: 1:500-1:1000

Conjugate

Unconjugated

Specificity

Confirmed by WB using soluble mouse and human brain extracts, reactivity for major product diminished by peptide absorption. Does not detect alpha-synuclein as tested with recombinant protein and does not react with Lewy bodies in human Dementia with Lewy Bodies or Parkinson's disease brain tissue sections.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

beta-synuclein

UniProt ID

Q16143
UniProt Summary: Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.

NCBI Gene ID

6620

Shipping

25°C (ambient)

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Anti-Beta-synuclein Antibody

SKU: R-1683-500

Product Details

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