Anti-Beta-nerve growth factor (beta-NGF) Antibody

Name: Anti-Beta-nerve growth factor (beta-NGF) Antibody
Brand: Biosensis
SKU: S-050-250
Price: 337.0 USD
Availability: InStock

Our Anti-Beta-nerve growth factor (beta NGF) sheep polyclonal primary antibody detects avian, human, mouse, and rat Beta-nerve growth factor (beta NGF), and is whole serum. It is validated for use in ELISA, IHC-Frozen, Neutralization, WB.

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Species Reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, Neutralize, WB

Host Species

Sheep

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Data Sheet

SKU: S-050-250

Volume/Size: 250 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Beta-nerve growth factor (beta NGF)

Scientific Background

FUNCTION: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons. SUBUNIT: Homodimer, associated by noncovalent forces. SUBCELLULAR LOCATION: Secreted protein. SIMILARITY: Belongs to the NGF-beta family.

Format

Whole serum

Clonality

Polyclonal

Isotype

Mixed

Applications

ELISA, IHC, Neutralize, WB

Host Species

Sheep

Immunogen

Native mouse beta NGF purified from submaxillary salivary gland (95% purity by PAGE)

Immunogen Species

Mouse

Species Reactivity

Human, Mouse, Rat

Storage

Spin vial briefly before opening. Reconstitute in 250 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Avoid repetitive freeze/thaw cycles. Glycerol (1:1) may be added for an additional stability.

Physical State

Lyophilized

Dilution Ranges

WB: 1:1000-1:5000
IHC: 1:1000-1:5000
ELISA: 1:15000

Application Details

For inhibition of biological activity: 1:10-50 for in vitro, 5-10 µL/g body weight for in vivo. This antiserum completely inhibits neuronal survival and the outgrowth actions of murine NGF in chicken DRG in vitro.

Conjugate

Unconjugated

Specificity

A cross reactivity of less than 1% to recombinant human BDNF, NT3, NT4/5 by ELISA has been shown. This antiserum is known to cross react with mouse, rat, human and avian NGF but not bovine NGF.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

nerve growth factor; Beta-nerve growth factor; beta

UniProt ID

P01139
UniProt Summary: Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (Probable). The immature NGF precursor (proNGF) functions as a ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI. Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form.

NCBI Gene ID

18049

Shipping

25°C (ambient)

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Anti-Beta-nerve growth factor (beta-NGF) Antibody

SKU: S-050-250

Product Details

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