Anti-Beta Amyloid Antibody

Name: Anti-Beta Amyloid Antibody
Brand: Biosensis
SKU: R-959-100
Price: 337.0 USD
Availability: InStock

Our Anti-Beta Amyloid rabbit polyclonal primary antibody detects human Beta Amyloid, and is whole serum. It is validated for use in ELISA.

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Species Reactivity

Human

Applications

ELISA

Host Species

Rabbit

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Data Sheet

SKU: R-959-100

Volume/Size: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Beta Amyloid

Scientific Background

The beta Amyloid peptide is derived from the cleavage of the Amyloid precursor protein and varies in length from 39 to 43 amino acids. Beta amyloid peptides are the major constituents of the plaques and tangles that occur in Alzheimer's disease.

Format

Whole serum

Clonality

Polyclonal

Isotype

Mixed

Applications

ELISA

Host Species

Rabbit

Immunogen

A synthetic peptide (DAEFRHDSGYEVHH) conjugated to bovine serum albumin (BSA) corresponding to amino acid sequence 1-14 of mature human beta amyloid.

Immunogen Species

Human

Species Reactivity

Human

Storage

Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. At least 12 months after purchase at 2-8°C (lyophilized formulations). After reconstitution, aliquot and store at -20°C for a higher stability and at 2-8°C with an appropriate antibacterial agent. Avoid freeze-thaw cycles.

Physical State

Lyophilized

Conjugate

Unconjugated

Specificity

Human beta amyloid, cross reactivity to APP has not bee tested.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

A4 amyloid protein; APP; A4_HUMAN; Amyloid beta A4 protein; AAA; ABPP; ABETA; Abeta; ABPP; APPI; AD1; AICD-50; AD1; AICD-57; AICD-59; AID(50; AID(57; AID(59; Alzheimer disease amyloid protein; Amyloid beta (A4 precursor protein; Amyloid beta A4 protein; Amyloid beta protein; Amyloid intracellular domain 50; Amyloid intracellular domain 57; Amyloid intracellular domain 59; Amyloid precursor protein; APP; APPI; Beta amyloid peptide; Beta-amyloid precursor protein; Beta-APP40; Beta-APP42; C31; Cerebral vascular amyloid peptide; CTFgamma; CVAP; Gamma-CTF(50; Gamma-CTF(57; Gamma-CTF(59; peptidase nexin II; PN 2; PN II; PN-II; PN2; PreA4; Protease nexin II; Protease nexin-II; S-APP-alpha; S-APP-beta

UniProt ID

P05067
UniProt Summary: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(o) and JIP. Inhibits G(o) alpha ATPase activity. Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. By acting as a kinesin I membrane receptor, plays a role in axonal anterograde transport of cargo towards synapses in axons. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1.

NCBI Gene ID

351

Shipping

25°C (ambient)

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Anti-Beta Amyloid Antibody

SKU: R-959-100

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