Anti-Beta-3 adrenergic receptor (ADRB3) Antibody

Name: Anti-Beta-3 adrenergic receptor (ADRB3) Antibody
Brand: Biosensis
SKU: C-1529-100
Price: 347.0 USD
Availability: InStock

Our Anti-Beta-3 adrenergic receptor (ADRB3) chicken polyclonal primary antibody detects mouse and rat Beta-3 adrenergic receptor (ADRB3), and is affinity-purified. It is validated for use in ELISA, WB.

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Species Reactivity

Mouse, Rat

Applications

ELISA, WB

Host Species

Chicken

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Data Sheet

SKU: C-1529-100

Volume/Size: 100 µL

Variant

Price:

$347.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Beta-3 adrenergic receptor (ADRB3)

Scientific Background

Beta-adrenergic receptors are multi-pass membrane proteins that belong to the G-protein coupled receptor 1 family. Their function is to mediate the catecholamine-induced activation of adenylate cyclase through the action of G-proteins (ref: SWISSPROT).

Format

Affinity-purified

Clonality

Polyclonal

Isotype

IgY

Applications

ELISA, WB

Host Species

Chicken

Molecular Weight

44 kDa

Immunogen

A synthetic peptide from mouse beta 3 Adrenergic Receptor (386-400 aa).

Immunogen Species

Mouse

Species Reactivity

Mouse, Rat

Storage

Short term storage at 2-8°C for one week. At -20°C as an undiluted liquid for up to 12 months.

Physical State

Liquid

Buffer

PBS with 0.02% sodium azide.

Dilution Ranges

WB: 1:2000-1:5000
ELISA: 1:2000-1:5000

Conjugate

Unconjugated

Specificity

This antibody detects ADRB3 in mouse and rat at approx 44 kDa. mouse, rat.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

Adrb-3; ADRB3; Beta-3 AR; Beta-3 adrenergic receptor; Beta-3 adrenoceptor; Beta-3 adrenoreceptor; beta 3-AR; beta3-adrenergic receptor; Adrb3r; B3bar; mouse adrenergic b3 receptor

UniProt ID

P25962
UniProt Summary: G protein-coupled receptor for catecholamines that couples to both G(s) and G(i) proteins, leading to either activation or inhibition of adenylate cyclase and cAMP-dependent pathway, respectively. The rank order of potency for physiological agonists is norepinephrine > epinephrine. Involved in the regulation of thermogenesis and lipolysis in brown and white adipose tissue, after coupling to G(s) proteins and stimulation of the cAMP-PKA axis. Also activates lipolytic process by coupling to G(i) proteins and consequent initiation of the ERK1/2 MAP kinase cascade. Participates in relaxation of the blood vessels and the urinary bladder. Also mediates negative inotropic effects in cardiomyocytes through activation of an NO synthase pathway and subsequent increase in cGMP levels, possibly involving G(i/o) protein-mediated coupling.

NCBI Gene ID

11556

Shipping

2-8°C (on cold packs)

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Anti-Beta-3 adrenergic receptor (ADRB3) Antibody

SKU: C-1529-100

Product Details

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