Anti-Beclin-1 Antibody

Name: Anti-Beclin-1 Antibody
Brand: Biosensis
SKU: R-141-100
Price: 337.0 USD
Availability: InStock

Our Anti-Beclin-1 rabbit polyclonal primary antibody detects human Beclin-1, and is whole serum. It is validated for use in IHC-Frozen.

Confocal microscopy of cytospin-isolated human white blood cells, stained with rabbit anti-Beclin-1 antibody (R-141-100 at 1:200, red), reveals classic punctate pattern consistent with localization to autophagosomes. Co-staining performed with anti-Myeloperoxidase (MPO, green) and a Hoechst nuclear counterstain (blue), identifying both MPO-positive neutrophils and MPO-negative lymphocytes. Detection of Beclin-1 with varying signal intensity in these distinct cell types reflects their different real-time levels of autophagic activity.

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Species Reactivity

Human

Applications

IHC

Host Species

Rabbit

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Data Sheet

SKU: R-141-100

Volume/Size: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Beclin-1

Scientific Background

Beclin-1 plays a central role in autophagy. It may also play a role in antiviral host defense. It is ubiquitously expressed and it localises to the cytoplasm, golgi apparatus membrane, and in dendrites and cell bodies of cerbellar Purkinje cells. The unprocessed precursor has a length of 450 amino acids and an estimated molecular weight of 51.89 kDa.

Format

Whole serum

Clonality

Polyclonal

Isotype

Mixed

Applications

IHC

Host Species

Rabbit

Immunogen

C-terminal of human Beclin-1 conjugated to Blue Carrier Protein.

Immunogen Species

Human

Species Reactivity

Human

Storage

Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Avoid repetitive freeze/thaw cycles.

Physical State

Lyophilized

Dilution Ranges

IHC: 1:100-1:2000

Conjugate

Unconjugated

Specificity

Specific for Beclin-1. Human, other species have not yet been tested.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

PG6; Coiled-coil myosin-like BCL2-interacting protein; ATG 6; Protein GT197; ATG6; APG 6; ATG6 autophagy related 6 homolog; BECN1; Bcl-2-interacting protein beclin; Beclin 1 (coiled coil moesin like BCL2 interacting protein; Beclin 1 autophagy related; Beclin-1; Beclin1; BECN 1; Becn1; BECN1_HUMAN; Coiled coil myosin like BCL2 interacting protein; Coiled-coil myosin-like BCL2-interacting protein; GT197; Protein GT197; VPS 30; VPS30

UniProt ID

Q14457
UniProt Summary: Plays a central role in autophagy. Acts as a core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis. May play a role in antiviral host defense.

NCBI Gene ID

8678

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Anti-Beclin-1 Antibody

SKU: R-141-100

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