Anti-Adenosine triphosphate (ATP)- ase (ATPase) Antibody

Name: Anti-Adenosine triphosphate (ATP)- ase (ATPase) Antibody
Brand: Biosensis
SKU: R-072-100
Price: 337.0 USD
Availability: InStock

Our Anti-Adenosine triphosphate (ATP)- ase (ATPase) rabbit polyclonal primary antibody detects human and rat Adenosine triphosphate (ATP)- ase (ATPase), and is whole serum. It is validated for use in IHC-Frozen.

IHC on rat trigeminal nerve (free floating cryo section) using Rabbit antibody to human ATPase (195-209): whole serum (R-072-100) at a dilution of 1: 2000.

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Species Reactivity

Human, Rat

Applications

IHC

Host Species

Rabbit

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Data Sheet

SKU: R-072-100

Volume/Size: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Adenosine triphosphate (ATP)- ase (ATPase)

Scientific Background

CATALYTIC ACTIVITY: ATP + H2O = ADP + phosphate. SUBCELLULAR LOCATION: Membrane; multi-pass membrane protein (By similarity). ALTERNATIVE PRODUCTS: 2 named isoforms produced by alternative splicing. SIMILARITY: Belongs to the cation transport ATPase (P-type) family. Type V subfamily.

Format

Whole serum

Clonality

Polyclonal

Isotype

Mixed

Applications

IHC

Host Species

Rabbit

Immunogen

A synthetic peptide (C-DDVHRSRHGLSLQDQ) as part of human ATP13A2 protein (aa: 195-209) conjugated to KLH

Immunogen Species

Human

Species Reactivity

Human, Rat

Storage

Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

Physical State

Lyophilized

Dilution Ranges

IHC: 1:500-1:2000

Conjugate

Unconjugated

Specificity

Immunohistochemistry shows specific staining for ATPase. This antiserum is known to react with rat ATPase. Other species have not yet tested.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

cation-transporting ATPase 13A2; Probable cation-transporting ATPase 13A2; CLN12; EC 3.6.3.-; KRPPD; ATP13A2; PARK9; SPG78; ATPase 13A2; ATPase type 13A2

UniProt ID

Q9NQ11
UniProt Summary: ATPase which acts as a lysosomal polyamine exporter with high affinity for spermine. Also stimulates cellular uptake of polyamines and protects against polyamine toxicity. Plays a role in intracellular cation homeostasis and the maintenance of neuronal integrity. Contributes to cellular zinc homeostasis. Confers cellular protection against Mn(2+) and Zn(2+) toxicity and mitochondrial stress. Required for proper lysosomal and mitochondrial maintenance. Regulates the autophagy-lysosome pathway through the control of SYT11 expression at both transcriptional and post-translational levels. Facilitates recruitment of deacetylase HDAC6 to lysosomes to deacetylate CTTN, leading to actin polymerization, promotion of autophagosome-lysosome fusion and completion of autophagy. Promotes secretion of exosomes as well as secretion of SCNA via exosomes. Plays a role in lipid homeostasis.

NCBI Gene ID

23400

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Anti-Adenosine triphosphate (ATP)- ase (ATPase) Antibody

SKU: R-072-100

Product Details

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