Anti-Activity-regulated gene 3.1 protein homolog (Arg3.1) Antibody

Name: Anti-Activity-regulated gene 3.1 protein homolog (Arg3.1) Antibody
Brand: Biosensis
SKU: R-173-500
Price: 337.0 USD
Availability: InStock

Our Anti-Activity-regulated gene 3.1 protein homolog (Arg3.1) rabbit polyclonal primary antibody detects human, mouse, and rat Activity-regulated gene 3.1 protein homolog (Arg3.1), and is IgG. It is validated for use in IHC-Frozen.

Immunohistochemical detection of Arg3.1 in free floating cryosectioned rat brain (Cortex) using Rabbit antibody to Arg3.1 (ARC): IgG (R-173-500) at a concentration of 2 µg/mL.

Immunohistochemical detection of Arg3.1 in free floating cryosectioned rat spinal cord (ventral horn) using Rabbit antibody to Arg3.1 (ARC): IgG (R-173-500) at a concentration of 2 µg/mL.

Immunohistochemical detection of Arg3.1 in free floating cryosectioned rat spinal cord (dorsal horn) using Rabbit antibody to Arg3.1 (ARC): IgG (R-173-500) at a concentration of 2 µg/mL.

Immunohistochemical detection of Arg3.1 in free floating cryosectioned rat brain (Cortex) using Rabbit antibody to Arg3.1 (ARC): IgG (R-173-500) at a concentration of 2 µg/mL.

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Species Reactivity

Human, Mouse, Rat

Applications

IHC

Host Species

Rabbit

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Data Sheet

SKU: R-173-500

Volume/Size: 500 µg

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Activity-regulated gene 3.1 protein homolog (Arg3.1)

Scientific Background

Arc (also termed activity-regulated cytoskeleton-associated protein or Arg3.1), is an effector immediate early gene whose upregulation has been demonstrated during events of synaptic plasticity. Arg3.1 expression is detectable in neuronal cell bodies and dendrites in the brain regions including striatum and cortex hippocampus, hypothalamus, amygdala.

Format

IgG

Clonality

Polyclonal

Isotype

IgG

Applications

IHC

Host Species

Rabbit

Immunogen

A synthetic peptide from the C terminal of human Arg3.1 protein (ARC protein) conjugated to Blue Carrier Protein. The sequence is homologous with mouse and rat form of Arg3.1.

Immunogen Species

Human

Species Reactivity

Human, Mouse, Rat

Storage

Spin vial briefly before opening. Reconstitute in 500 µL sterile-filtered 1X PBS, pH 7.2-7.6. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

Physical State

Lyophilized

Production Notes

Protein G purified IgG

Buffer

Lyophilized from a solution containing PBS pH 7.4

Dilution Ranges

IHC: 2-4 µg/mL

Conjugate

Unconjugated

Specificity

Specific for Arg3.1. Rat and mouse. Other species not yet tested.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

Arg3.1; ARC; ARC/ARG3.1; activity regulated cytoskeletal-associated protein; activity-regulated gene 3.1 protein homolog; RCA/ARG3.1

UniProt ID

Q7LC44
UniProt Summary: Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation. ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons. Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory. Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis. Acts as a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum by mediating elimination of surplus climbing fiber synapses. Accumulates at weaker synapses, probably to prevent their undesired enhancement. This suggests that ARC-containing virion-like capsids may be required to eliminate synaptic material. Required to transduce experience into long-lasting changes in visual cortex plasticity and for long-term memory. Involved in postsynaptic trafficking and processing of amyloid-beta A4 (APP) via interaction with PSEN1. In addition to its role in synapses, also involved in the regulation of the immune system: specifically expressed in skin-migratory dendritic cells and regulates fast dendritic cell migration, thereby regulating T-cell activation.

NCBI Gene ID

23237

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Anti-Activity-regulated gene 3.1 protein homolog (Arg3.1) Antibody

SKU: R-173-500

Product Details

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