Anti-GABA-A-R-Alpha4 Antibody FL490 Conjugate (N398A/34)

Name: Anti-GABA-A-R-Alpha4 Antibody FL490 Conjugate
Brand: NeuroMab
SKU: 75-383-FL490
Price: 543.0 USD
Availability: InStock

Our mouse GABA-A-R-Alpha4 FL490 conjugate monoclonal antibody from NeuroMab is produced in-house from clone N398A/34. It detects mouse and rat GABA-A-R-Alpha4 and is purified by Protein A chromatography. Works in IHC, ICC.

Anti-GABA-A-R-Alpha4 Antibody FL490 Conjugate

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Species Reactivity

Mouse, Rat

Applications

ICC, IHC

Host Species

Mouse

Conjugates and Formulations

Unconjugated

550

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: 75-383-FL490

Volume: 200 µL

Variant

Price:

$543.00

Quantity:

Ships: 1-5 business days

Product Details

Target

GABA-A-R-Alpha4

Scientific Background

Gamma-aminobutyric acid receptor subunit alpha-4 or GABA AR alpha4 is encoded by the gene GABRA4. GABAA receptors are members of the Cys-loop family of ligand-gated ion channels. GABA AR alpha 4 is a subunit of the pentameric GABA receptors where GABA is the major inhibitory neurotransmitter in the vertebrate brain and mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. GABA AR alpha 4 has been found to be expressed in skeletal muscle tissue, adult mammalian kidney, heart and primarily in brain at the cell junction, synapse,and the postsynaptic cell membrane. Disorders involving the GABRA4 gene include autism, Status Epilepticus and restless legs syndrome.

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

N398A/34

Isotype

IgG1

Applications

ICC, IHC

Host Species

Mouse

Gene Name

Gabra4

Molecular Weight

60 kDa

Immunogen

Fusion protein amino acids 410-450 (cytoplasmic C-terminus) of rat GABA-A-R-Alpha4 (accession number P28471) produced recombinantly in E. Coli

Immunogen Species

Rat

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2940268

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

FL490 Ex: 491 nm, Em: 515 nm

Specificity

Does not cross-react with other GABA-A receptor Alpha subunits

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

Gamma-aminobutyric acid receptor subunit alpha-4 (GABA(A) receptor subunit alpha-4)

UniProt ID

P28471

Shipping

Shipped on ice packs

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Anti-GABA-A-R-Alpha4 Antibody FL490 Conjugate (N398A/34)

SKU: 75-383-FL490

Product Details

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