Anti-Myelin Basic Protein (MBP) Antibody

Name: Anti-Myelin Basic Protein (MBP) Antibody
Brand: Antibodies Incorporated
SKU: RP-4015
Price: 337.0 USD
Availability: InStock

Our rabbit Mylein Basic Protein polyclonal antibody from Antibodies Incorporated is produced in-house. It detects human Mylein Basic Protein and is purified by Protein A chromatography. Works in IHC, ICC, WB, ELISA.

Representative sections of formalin fixed, paraffin-embedded rat brain showing staining of Myelin Basic Protein (MBP). The sections were stained with rabbit polyclonal anti-MBP antibody at 1:1000 dilution and detected with anti-mouse HRP.

Western blotting of rat brain homogenates using 0.2 ug/mL, 1 ug/mL, or 5 ug/mL rabbit polyclonal anti-Myelin Basic Protein (MBP) (RP-4015). RP-4015 rabbit anti-MBP recognizes endogenous MBP at 20 kDa.

Representative sections of formalin fixed, paraffin-embedded rat brain showing staining of Myelin Basic Protein (MBP). The sections were stained with rabbit polyclonal anti-MBP antibody at 1:1000 dilution and detected with anti-mouse HRP.

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Species Reactivity

Human

Applications

ELISA, ICC, IHC, WB

Host Species

Rabbit

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: RP-4015

Volume: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Mylein Basic Protein

Scientific Background

Myelin Basic Protein (MBP) a 19.6 kDa highly basic protein is a major constituent of central nervous system (CNS). This protein is synthesized by oligodendrocyte and Schwann cells. MBP, Proteolipid (PLP), myelin oligodendrocyte glycoprotein (MOG) are primary encephaltogenic target antigens in multiple sclerosis. The gene for MBP is on chromosome 18; the protein localizes to CNS and to various cells of the hematopoietic system. MBP is expressed in oligodendrocyte, myelin of white matter, spinal cord and in peripheral nerves. This antibody stains white matter and oligodendrocyte.

Format

Purified by Protein A Chromatography

Concentration

1 mg/mL

Clonality

Polyclonal

Isotype

IgG

Applications

ELISA, ICC, IHC, WB

Host Species

Rabbit

Gene Name

MBP

Molecular Weight

20 kDa

Immunogen Species

Human

Species Reactivity

Human

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Prepared from pooled rabbit serum by Protein A affinity chromatography.

Buffer

1X PBS, 0.05% Sodium Azide pH 7.4

Dilution Ranges

WB: 1:1000
IHC: 1:500 - 1:1000
ICC: 1:500 - 1:1000

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used in Western blot.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

GDB; MBP; Golli MBP; Myelin membrane encephalitogenic protein; Golli MBP myelin basic protein; Myelin A1 protein; Hemopoietic MBP; HMBPR; HUGO; MBP; MBP_CAVPO; MBP_HUMAN; MGC99675; MLD; Myelin A1 protein; Myelin A1 Protein basic; Myelin basic protein; Myelin Deficient; Myelin membrane encephalitogenic protein; OTTHUMP00000163776 m; OTTHUMP00000174387; OTTHUMP00000174388; SHI; Shiverer; SP

UniProt ID

P02686
UniProt Summary: The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.

NCBI Gene ID

4155

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Anti-Myelin Basic Protein (MBP) Antibody

SKU: RP-4015

Product Details

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