Anti-Gamma-synuclein Antibody

Name: Anti-Gamma-synuclein Antibody
Brand: Biosensis
SKU: R-058-100
Price: 337.0 USD
Availability: InStock

Our Anti-Gamma-synuclein rabbit polyclonal primary antibody detects human and rat Gamma-synuclein, and is whole serum. It is validated for use in IHC-Frozen, WB.

Immunohistochemical staining of gamma synuclein in rat brainstem using rabbit polyclonal to human gamma synuclein, catalogue number R-058-100.

Immunohistochemical staining of gamma synuclein in rat brain tissue using rabbit polyclonal to human gamma synuclein, catalogue number R-058-100.

Immunohistochemical staining of gamma synuclein in rat brainstem using rabbit polyclonal to human gamma synuclein, catalogue number R-058-100.

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Species Reactivity

Human, Rat

Applications

IHC, WB

Host Species

Rabbit

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Data Sheet

SKU: R-058-100

Volume/Size: 100 µL

Variant

Price:

$337.00

Quantity:

Product Details

Target

Gamma-synuclein

Scientific Background

FUNCTION: Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases. May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway. SUBUNIT: May be a centrosome-associated protein. SUBCELLULAR LOCATION: Cytoplasm; perinuclear region. Centrosome. Spindle. Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle. TISSUE SPECIFICITY: Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung. PTM: Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases. DISEASE: Brain iron accumulation type 1 (NBIA1, also called Hallervorden-Spatz syndrome), a rare neuroaxonal dystrophy, is histologically characterized by axonal spheroids, iron deposition, Lewy body (LB)-like intraneuronal inclusions, glial inclusions and neurofibrillary tangles. SNCG is found in spheroids but not in inclusions. SIMILARITY: Belongs to the synuclein family.

Format

Whole serum

Clonality

Polyclonal

Isotype

Mixed

Applications

IHC, WB

Host Species

Rabbit

Immunogen

A synthetic peptide (EKEEVAEEAQSGGD) as part of human gamma synuclein protein (aa: 114-127) conjugated to diptheria toxid has been used as the immunogen.

Immunogen Species

Human

Species Reactivity

Human, Rat

Storage

Spin vial briefly before opening. Reconstitute in 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

Physical State

Lyophilized

Dilution Ranges

WB: 1:500-1:1000
IHC: 1:500-1:1000

Conjugate

Unconjugated

Specificity

Immunohistochemical/Western blot analysis indicate a high level of specificity for this antiserum for gamma synuclein. This antiserum is known to react with human and rat gamma synuclein.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

Persyn; Breast cancer-specific gene 1 protein; Synoretin; BCSG1; PERSYN; PRSN; SNCG; SR;

UniProt ID

O76070

Shipping

25°C (ambient)

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Anti-Gamma-synuclein Antibody

SKU: R-058-100

Product Details

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