Anti-Alpha-Calcitonin Gene-Related Peptide (alpha-CGRP) Antibody (5)

Name: Anti-Alpha-Calcitonin Gene-Related Peptide (alpha-CGRP) Antibody
Brand: Antibodies Incorporated
SKU: ABS 026-05-010
Price: 425.0 USD
Availability: InStock

Our mouse Alpha-Calcitonin Gene-Related Peptide (Alpha-CGRP) monoclonal antibody from Antibodies Incorporated is produced in-house from clone 5. It detects human and rat Alpha-Calcitonin Gene-Related Peptide (Alpha-CGRP) and is Protein A or Protein G purified. Works in ELISA, IHC.

Immunohistochemistry detection of Alpha-calcitonin gene-related peptide (α-CGRP) in rat tissue tissue using Anti-Alpha-Calcitonin Gene-Related Peptide (alpha-CGRP) Antibody (Cat. ABS 026-05-010). Tissue was mounted and pariffin fixed. Heat induced antigen retrieval was performed using citrate buffer, heated, and then blocked. After washing, the primary antibody (Cat. ABS 026-05-010) was incubated with the sample.

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Species Reactivity

Human

Applications

ELISA, IHC

Host Species

Mouse

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Data Sheet

SKU: ABS 026-05-010

Volume: 100 uL

Variant

Price:

$425.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Alpha-Calcitonin Gene-Related Peptide (Alpha-CGRP)

Scientific Background

Calcitonin gene-related peptide is a 37 amino acid vasoactive neuropeptide (MW 3789) widely expressed throughout the central and peripheral nervous system. CGRP has potent vasodilatory effects probably serving as a regulator of regional blood flow, In addition to a variety of other cellular effects.

Format

Protein A or Protein G purified

Concentration

1 mg/mL ±15%

Clonality

Monoclonal

Clone

Isotype

IgG1/k

Applications

ELISA, IHC

Host Species

Mouse

Gene Name

CALCA

Molecular Weight

11 kDa (pro-CGRP), 5 kDa (active)

Immunogen

Synthetic human α-CGRP

Immunogen Species

Human

Species Reactivity

Human

Storage

2-8°C without exposure to light

Physical State

Liquid

Production Notes

BSA free

Buffer

0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide

Dilution Ranges

IHC: 1:100

Application Details

ABS 026-05 binds free α-CGRP in solution. Based on inhibition ELISA, the affinity of ABS 026-05 is at least 24 times higher than that of ABS 026-04. ABS 026-05 (as capture antibody) forms a sandwich ELISA pair with ABS 026-04 (as biotinylated detection antibody) for measuring human a-CGRP, giving a detection limit of 0.13 nmol/L in an unoptimized buffer assay. ABS 026-05 works well in IHC on paraffin embedded tissue.

Conjugate

Unconjugated

Specificity

ABS 026-05 binds human α-CGRP. Based on inhibition ELISA, ABS 026-05 shows full cross-reactivity with rat α-CGRP and about 50% cross-reactivity with human b-CGRP. There is no cross-reaction with human amylin. The epitope lies within residues 1-18 of human α-CGRP.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

CALCA, CALC1, CGRP, CGRP-I, CGRP-alpha, CGRP1, CT, KC, PCT, calcitonin, calcitonin gene-related peptide 1, alpha-type CGRP, calcitonin 1, calcitonin gene-related peptide I, calcitonin/calcitonin-related polypeptide, alpha, katacalcin

UniProt ID

P06881

NCBI Gene ID

796

Shipping

Shipped on ice packs

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Anti-Alpha-Calcitonin Gene-Related Peptide (alpha-CGRP) Antibody (5)

SKU: ABS 026-05-010

Product Details

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