SynaptoRedTM C1 Nerve Terminal Dye

Name: SynaptoRedTM C1 Nerve Terminal Dye
Brand: Antibodies Incorporated
SKU: 81-8001
Price: 389.0 USD
Availability: InStock

Our SynaptoRedTM C1 Nerve Terminal Dye is a widely used red fluorescent dye for following synaptic activity by staining synaptic vesicles at the synapse or neuromuscular junctions.

Applications

EM, ICC, IHC

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SKU: 81-8001

Size: 5 x 1 mg

Variant

Price:

$389.00

Quantity:

Ships: 1-5 business days

Product Details

Scientific Background

Nerve terminal dyes have highly hydrophilic, cationically charged head groups at one end with lipophilic tails at the other end. They are virtually non-fluorescent in aqueous solution, but become intensely fluorescent in membranes. Following nerve stimulation, the dye molecules are internalized in newly formed endocytic vesicles. During exocytosis, the dyes are released from the vesicles along with neurotransmitters, causing a decrease in fluorescence signal. As a result, the change in fluorescent intensity reflects the amount of endocytosis/exocytosis or synaptic activity. SynaptoRedTM C1 is a widely used red fluorescent dye for following synaptic activity by staining synaptic vesicles at the synapse or neuromuscular junctions. When used in combination with the green fluorescent dye SynaptoGreen™ , synapses or neuromuscular junctions can be imaged independently in two colors. SynaptoRed™ has also been used to study endocytosis in Dictyostelia. SynaptoRed™ C1 is similar to the widely used red fluorescent nerve terminal dye SynaptoRed™ C2 (also called FM®4-64) except that the lipophilic tail of SynaptoRed™ C1 is one carbon shorter than that of the SynaptoRed™ C2. Thus, SynaptoRed™ C1 is expected to have a faster off-rate compared to SynaptoRed™ C2.

Applications

EM, ICC, IHC

Molecular Weight

580 Da

Excitation / Emission

Ex: 510 nm, Em: 750 nm (in membranes)

Storage

Store at 2°C to 8°C, with desiccant; protect from light.

Physical State

Solid

Specificity

For use in real-time imaging of live/intact cells.

Usage Statement

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Country of Origin

United States

Expiration

Stable for 12 months after date of receipt.

Shipping

Shipped at ambient temperature with desiccant; protected from light

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SynaptoRedTM C1 Nerve Terminal Dye

SKU: 81-8001

Product Details

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