Anti-PSD-95 Antibody Biotin Conjugate (K28/43)

Name: Anti-PSD-95 Antibody Biotin Conjugate
Brand: NeuroMab
SKU: 75-028-BTN
Price: 543.0 USD
Availability: InStock

Our mouse PSD 95 biotin conjugate monoclonal antibody from NeuroMab is produced in-house from clone K28/43. It detects chicken, human, mouse, non-human primate, and rat PSD 95 and is purified by Protein A chromatography. KO validated. Works in ELISA, IHC, ICC, WB, IP.

Anti-PSD-95 Antibody Biotin Conjugate

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Species Reactivity

Chicken, Human, Mouse, Non-Human Primate, Rat

Applications

ELISA, ICC, IHC, IP, WB

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

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Data Sheet

KO Validated

Trial Size

SKU: 75-028-BTN

Volume: 200 µL

Variant

Price:

$543.00

Quantity:

Ships: 1-5 business days

Product Details

Target

PSD 95

Scientific Background

PSD-95 is a member of the MAGUK (membrane associated guanylate kinase) family (which also includes PSD-93, SAP97 and SAP102) and functions as a scaffold protein that can cluster membrane receptors, ion channels, including NMDA receptor subunits, Kv1 potassium channels and Caspr2. The protein is encoded by DLG4, contains hallmark PDZ, SH3 and GuK domains and is found at post synaptic densities where it plays an important role in the formation and maintenance of synaptic junctions (Zhou and Blumberg, 2003). Indeed, overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. Antibodies against PSD95/DLG4 are frequently used in conjunction with pre-synaptic markers to localize synapses by microscopy

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

K28/43

Isotype

IgG2a

Applications

ELISA, ICC, IHC, IP, WB

Host Species

Mouse

Gene Name

DLG4 PSD95

Molecular Weight

95-110 kDa (varies with cell background due to phosphorylation)

Immunogen

Fusion Protein Amino acids 77-299 (PDZ domains 1 and 2) of human PSD-95 (accession number P78352) produced recombinantly in E. Coli

Immunogen Species

Human

Species Reactivity

Chicken, Human, Mouse, Non-Human Primate, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

Biotin

Specificity

No cross-reactivity against recombinant Chapsyn-110, SAP97 or SAP102

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)

UniProt ID

P78352

Shipping

Shipped on ice packs

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Anti-PSD-95 Antibody Biotin Conjugate (K28/43)

SKU: 75-028-BTN

Product Details

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