Anti-Pregnancy Associated Plasma Protein A (PAPP-A) Antibody (PAPP A 1-24)

Name: Anti-Pregnancy Associated Plasma Protein A (PAPP-A) Antibody
Brand: Antibodies Incorporated
SKU: ABS 006-24-010
Price: 325.0 USD
Availability: InStock

Our mouse Pregnancy Associated Plasma Protein A (PAPP-A) monoclonal antibody from Antibodies Incorporated is produced in-house from clone PAPP A 1-24. It detects human Pregnancy Associated Plasma Protein A (PAPP-A) and is Protein A or Protein G purified. Works in ELISA, IHC, WB.

Immunohistochemistry detection of Pregnancy associated plasma protein A (PAPP-A) in human placental tissue using Anti-Pregnancy Associated Plasma Protein A (PAPP-A) Antibody (Cat. ABS 006-24-010). Tissue was mounted and pariffin fixed. Heat induced antigen retrieval was performed using citrate buffer, heated, and then blocked. After washing, the primary antibody (Cat. ABS 006-24-010) was incubated with the sample.

Click on image to zoom

Species Reactivity

Human

Applications

ELISA, IHC, WB

Host Species

Mouse

Go to Full Product Details

Data Sheet

SKU: ABS 006-24-010

Volume: 100 uL

Variant

Price:

$325.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Pregnancy Associated Plasma Protein A (PAPP-A)

Scientific Background

Pregnancy-associated plasma protein-A (PAPP-A, Insulin-like growth factor binding protein-4 protease, PAPP-A-proMBP complex) is a large heterotetrameric glycoprotein of approximately 500 kDa, which was first discovered in serum from pregnant women. The hetreotetramer consists of two PAPP-A subunits and two proMBP subunits. Low maternal serum levels of PAPP-A in first trimester biochemical screening is used as a marker of Down’s syndrome (trisomy 21).

Format

Protein A or Protein G purified

Concentration

1 mg/mL ±15%

Clonality

Monoclonal

Clone

PAPP A 1-24

Isotype

IgG1/k

Applications

ELISA, IHC, WB

Host Species

Mouse

Gene Name

PAPPA

Molecular Weight

500 kDa (tetramer), 180 kDa (monomer)

Immunogen

Purified human PAPP-A

Immunogen Species

Human

Species Reactivity

Human

Storage

2-8°C without exposure to light

Physical State

Liquid

Production Notes

BSA free

Buffer

0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide

Application Details

BTE 004-09 as coating antibody and biotinylated ABS 006-24 as a detection antibody is a good combination for sandwich ELISA. ABS 006-24 only detects unreduced PAPP-A in Western blotting. ABS 006-24 gives the strongest signal in IHC compared to ABS 006-01 and BTE 004-09.

Conjugate

Unconjugated

Specificity

ABS 006-24 is specific for native human PAPP-A. Heat and SDS denatured PAPP-A is also recognized, but not acid treated PAPP-A. The epitope of ABS 006-24 is different from BTE 004-09 and ABS 006-01. The epitope is located on the PAPP-A subunit of the heterotetramer.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

PAPPA, ASBABP2, DIPLA1, IGFBP-4ase, PAPA, PAPP-A, PAPPA1, pappalysin-1, IGF-dependent IGFBP-4 protease, aspecific BCL2 ARE-binding protein 2, differentially placenta 1 expressed protein, insulin-like growth factor-dependent IGF binding protein-4 protease, pregnancy-associated plasma protein A, pappalysin 1

UniProt ID

Q13219

NCBI Gene ID

5069

Shipping

Shipped on ice packs

Recover password

Create my account

Anti-Pregnancy Associated Plasma Protein A (PAPP-A) Antibody (PAPP A 1-24)

SKU: ABS 006-24-010

Product Details

Bulk Order Anti-Pregnancy Associated Plasma Protein A (PAPP-A) Antibody

Related Products

Recently Viewed