Anti-Pregnancy Associated Plasma Protein A (PAPP-A) Antibody (PAPP A 1-1)
Our mouse Pregnancy Associated Plasma Protein A (PAPP-A) monoclonal antibody from Antibodies Incorporated is produced in-house from clone PAPP A 1-1. It detects human Pregnancy Associated Plasma Protein A (PAPP-A) and is Protein A or Protein G purified. Works in ELISA, IHC, WB.
Anti-Pregnancy Associated Plasma Protein A (PAPP-A) Antibody
Pregnancy-associated plasma protein-A (PAPP-A, Insulin-like growth factor binding protein-4 protease, PAPP-A-proMBP complex) is a large heterotetrameric glycoprotein of approximately 500 kDa, which was first discovered in serum from pregnant women. The hetreotetramer consists of two PAPP-A subunits and two proMBP subunits. Low maternal serum levels of PAPP-A in first trimester biochemical screening is used as a marker of Down’s syndrome (trisomy 21).
Protein A or Protein G purified
1 mg/mL ±15%
Monoclonal
PAPP A 1-1
IgG1/k
ELISA, IHC, WB
Mouse
PAPPA
500 kDa (tetramer), 180 kDa (monomer)
Purified human PAPP-A
Human
Human
2-8°C without exposure to light
Liquid
BSA free
0.01 M phosphate buffer, pH 7.4, with 0.5 M NaCl and 15 mM sodium azide
In sandwich ELISA with a polyclonal antibody in coat, ABS 006-01 only reacts poorly with PAPP-A in third trimester serum. ABS 006-01 only detects unreduced PAPP-A in Western blotting.
Unconjugated
ABS 006-01 is specific for native human PAPP-A. The epitope of ABS 006-01 is different from BTE 004-09 and ABS 006-24. The epitope is located on the PAPP-A subunit of the heterotetramer.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
