Anti-Pan-Neurofascin Antibody (L11A/41)

Name: Anti-Pan-Neurofascin Antibody
Brand: NeuroMab
SKU: 75-027
Price: 337.0 USD
Availability: InStock

Our mouse Pan-Neurofascin monoclonal antibody from NeuroMab is produced in-house from clone L11A/41. It detects guinea pig, human, mouse, and rat Pan-Neurofascin and is purified by Protein A chromatography. Works in WB, IHC, ICC, ELISA.

Adult rat optic nerve immunofluorescence staining L11A/41 (5 μg/ml)=red Rabbit anti-Caspr=green Image courtesy of Dr. Matthew Rasband.

Adult rat optic nerve immunofluorescence staining L11A/41 (5 μg/ml)=red Rabbit anti-Caspr=green Image courtesy of Dr. Matthew Rasband.

Click on image to zoom

Species Reactivity

Guinea, Human, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: 75-027

Volume: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Pan-Neurofascin

Scientific Background

Neurofascin is encoded by the gene NFASC. Two major isoforms of NeuroFascin are expressed as a result of alternative splicing, NF186 and NF155. These proteins are expressed in the central nervous system. In brain, NF186 is expressed at Nodes of Ranvier andNF155 is expressed in unmyelinated axons. Neuofascin plays a role in cell adhesion and is thought to be involved in processes such as neurite extension, synaptogenesis and myelination. Diseases associated with this gene include Demyelinating Polyneuropathy.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

L11A/41

Isotype

IgG1

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Gene Name

Nfasc

Molecular Weight

155, 186 kDa (plus additional bands on immunoblot)

Immunogen

Fusion protein 1066-1174 (intracellular domain common to NF-155 and NF-186) of rat NF-155 (accession number AAL27854) produced recombinantly in E. Coli

Immunogen Species

Rat

Species Reactivity

Guinea, Human, Rat

Antibody Registry ID

AB_10672370

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

Neurofascin NF-155 NF-186

UniProt ID

AAL27854

Shipping

Shipped on ice packs

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Anti-Pan-Neurofascin Antibody (L11A/41)

SKU: 75-027

Product Details

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