Anti-Pan-Gamma-Protocadherin-Constant Antibody (N159/5)

Name: Anti-Pan-Gamma-Protocadherin-Constant Antibody
Brand: NeuroMab
SKU: 75-185
Price: 337.0 USD
Availability: InStock

Our mouse Pan-Gamma-protocadherin-Constant monoclonal antibody from NeuroMab is produced in-house from clone N159/5. It detects human, mouse, and rat Pan-Gamma-protocadherin-Constant and is purified by Protein A chromatography. Works in WB, IHC, ICC, ELISA.

Immunostaining of spinal cord samples from WT and Gamma-protocadherin KO mice with N159/5 TC supe. Data courtesy of Joshua Weiner, University of Iowa.

Transfected cell immunoblot: extracts of COS cells transiently transfected with GFP-tagged Gamma- protocadherin-A3, -B2 and -C4 and untagged Kv2.1 plasmids and probed with N159/5 (left) and N86/8 (right) TC supe.

And immunoblot versus brain samples from WT and Gamma-protocadherin KO mice with N159/5 TC supe. Data courtesy of Joshua Weiner, University of Iowa.

Immunostaining of spinal cord samples from WT and Gamma-protocadherin KO mice with N159/5 TC supe. Data courtesy of Joshua Weiner, University of Iowa.

Click on image to zoom

Species Reactivity

Mouse, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

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Data Sheet

KO Validated

SKU: 75-185

Volume: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Pan-Gamma-protocadherin-Constant

Scientific Background

Gamma-protocadherins belong to a superfamily of homophilic cell-adhesion proteins. These cell adhesion proteins are thought to be involved in establishing and function of cell-cell connections in brain. These proteins are widely expressed in the nervous system and brain.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N159/5

Isotype

IgG1

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Gene Name

Pcdhga3

Molecular Weight

100 kDa

Immunogen

Fusion protein corresponding to amino acids 808-931 (C-terminal cytoplasmic constant domain) of mouse Gamma-protocadherin-A1 that is shared by all 22 Gamma-protocadherins (A subfamily amino acids ~807-930, B subfamily amino acids ~789-912 and C subfamily amino acids ~818-941); produced recombinantly in E. Coli

Immunogen Species

Mouse

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2159449

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.113

Conjugate

Unconjugated

Specificity

Cross-reacts with all Gamma protocadherin-A, -B and -C proteins

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

Protocadherin gamma A3 (Protocadherin gamma subfamily A, 3)

UniProt ID

Q91XY5

Shipping

Shipped on ice packs

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Anti-Pan-Gamma-Protocadherin-Constant Antibody (N159/5)

SKU: 75-185

Product Details

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