Anti-Nav1.1 Na+ Channel Recombinant Chicken Chimeric mAb FL650 Conjugate (K74/71)

Name: Anti-Nav1.1 Na+ Channel Recombinant Chicken Chimeric mAb FL650 Conjugate
Brand: Aves Labs
SKU: 78-023-FL650
Price: 562.0 USD
Availability: InStock

Our chicken Anti-Nav1.1 Na+ channel FL650 conjugate recombinant monoclonal antibody is a chimeric antibody derived from NeuroMab clone K74/71. It detects human, mouse, non-human primate, and rat Nav1.1 Na+ channel and is purified by affinity chromatography. Works in ICC, IHC.

Anti-Nav1.1 Na+ Channel Recombinant Chicken Chimeric mAb FL650 Conjugate

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Applications

ICC, IHC

Host Species

Chicken

Conjugates and Formulations

Unconjugated

490

550

594

Biotin

Carrier-Free

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Data Sheet

SKU: 78-023-FL650

Volume: 200 µL

Variant

Price:

$562.00

Quantity:

Ships: 1-5 business days

Product Details

Target

Nav1.1 Na+ channel

Scientific Background

Nav1.1 Na+ channel (sodium channel, voltage-gated, type I, alpha subunit/ SCN1A) is a member of voltage-gated sodium ion channel subunit family. It is encoded by gene Scn1a in human.The channel switches between open and close conformation in response to the voltage difference accross the membrane. Nav1.1 Na+ channel is a sodium selective channel that maintains Na+ homeostasis by allowing Na+ ions to pass in accordance of their electrochemical gradient. The protein plays an important role in the release of neurotransmittors from the neurons. Therefore, Nav1.1 Na+ channel is involved in the perception of mechanical pain due to the activation of sematosensory neurons without the involvement of inflammation. Mutation of the gene encoding for Nav1.1 Na+ channel is one of the main cause of epilepsy and febrile seizures.

Format

Purified by affinity chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Recombinant

Clone

K74/71

Isotype

IgY

Applications

ICC, IHC

Host Species

Chicken

Gene Name

Scn1a

Molecular Weight

220 kDa

Excitation / Emission

FL650 Ex: 655 nm, Em: 676 nm

Immunogen

Fusion protein amino acids 1929-2009 (cytoplasmic C-terminus) of rat Nav1.1 (accession number P04774) produced recombinantly in E. Coli

Immunogen Species

Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

FL650 Ex: 655 nm, Em: 676 nm

Production Notes

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions of clone K74/71 with chicken IgY heavy and light constant regions. As such this antibody retains the same binding performance as the original clone K74/71 but can be detected using standard anti-chicken secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media and conjugated.

Buffer

1X PBS, 0.05% Sodium Azide pH 7.4

Conjugate

650

Specificity

No cross-reactivity with Nav1.2, Nav1.3 and Nav1.12

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

Sodium channel protein type 1 subunit alpha (Sodium channel protein brain I subunit alpha) (Sodium channel protein type I subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.1)

UniProt ID

P04774

Shipping

Shipped on ice packs

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Anti-Nav1.1 Na+ Channel Recombinant Chicken Chimeric mAb FL650 Conjugate (K74/71)

SKU: 78-023-FL650

Product Details

Bulk Order Anti-Nav1.1 Na+ Channel Recombinant Chicken Chimeric mAb FL650 Conjugate

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