Anti-MESD Antibody Biotin Conjugate (N88/12)

Name: Anti-MESD Antibody Biotin Conjugate
Brand: NeuroMab
SKU: 75-129-BTN
Price: 543.0 USD
Availability: InStock

Our mouse MESD biotin conjugate monoclonal antibody from NeuroMab is produced in-house from clone N88/12. It detects human, mouse, and rat MESD and is purified by Protein A chromatography. Works in ELISA, IHC, WB, IP.

Anti-MESD Antibody Biotin Conjugate

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Species Reactivity

Human, Mouse, Rat

Applications

ELISA, IHC, IP, WB

Host Species

Mouse

Conjugates and Formulations

Unconjugated

490

550

594

650

Carrier-Free

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Data Sheet

SKU: 75-129-BTN

Volume: 200 µL

Variant

Price:

$543.00

Quantity:

Ships: 1-5 business days

Product Details

Target

MESD

Scientific Background

Mesoderm Development LRP Chaperone is encoded by the gene MESD. MESD is a member of the MESD family. MESD is a chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). MESD acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. MESD is essential for the specification of embryonic polarity and mesoderm induction. MESD plays an essential role neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4. MESD is expressed in many tissues, but not in skeletal muscles. Diseases associated with MESD include Osteogenesis Imperfecta, Type Xx and Epilepsy, Nocturnal Frontal Lobe, 2.

Format

Purified by Protein A chromatography

Concentration

Lot dependent: provided at 0.3-0.5 mg/mL

Clonality

Monoclonal

Clone

N88/12

Isotype

IgG2b

Applications

ELISA, IHC, IP, WB

Host Species

Mouse

Gene Name

Mesd Mesdc2

Molecular Weight

26 kDa

Immunogen

Fusion Protein Amino acids 30-95 and 118-180 (lacking VSD domain) of mouse MESD (accession number Q9ERE7) produced recombinantly in E. Coli

Immunogen Species

Mouse

Species Reactivity

Human, Mouse, Rat

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography and conjugation of purified mAb. Purified mAbs are >90% specific antibody.

Buffer

PBS with 0.09% azide

Conjugate

Biotin

Specificity

No cross-reactivity reported

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

12 months from date of receipt

Synonyms

LRP chaperone MESD (LDLR chaperone MESD) (Mesoderm development candidate 2) (Mesoderm development protein)

UniProt ID

Q9ERE7

Shipping

Shipped on ice packs

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Anti-MESD Antibody Biotin Conjugate (N88/12)

SKU: 75-129-BTN

Product Details

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