Anti-LRP4 (Extracellular) Antibody (N207/27)

Name: Anti-LRP4 (Extracellular) Antibody
Brand: NeuroMab
SKU: 75-221
Price: 337.0 USD
Availability: InStock

Our mouse LRP4 (extracellular) monoclonal antibody from NeuroMab is produced in-house from clone N207/27. It detects human, mouse, rabbit, and rat LRP4 (extracellular) and is purified by Protein A chromatography. Works in WB, IHC, ICC, ELISA.

Representative images of EDL muscles of 3 M, 12 M, and 24 M-old mice, whole mount stained with 555-anti-LRP4 (Cat. 75-221, 1:200, red) and NF/Syn (blue). Arrowheads, non-annulospiral axons had no LRP4 expression. Arrows, LRP4 negative annulospiral endings in aged mice. Scale bar, 10 µm. Image from publication CC-BY-4.0. PMID:36765071

Western blot image of mouse skeletal muscle confirming of expression of Flag-LRP4 (Cat. 75-221, 1:1000). Image from publication CC-BY-4.0. PMID:36765071

Rat ColQ−/− muscle cells were transduced to express ColQ-Myc (+) or not (−). After differentiation, the myotubes were treated (+) or not (−) with 10 nM of neural agrin for 1 h, and MuSK tyrosine phosphorylation was assessed as aforementioned. E, MuSK and LRP4 (Cat. 75-221, 1:1000) cs levels of ColQ−/− myotubes re-expressing ColQ-Myc (+) or not (−) and not treated with agrin were analyzed. Image from publication CC-BY-4.0. PMID:37356721

Adult rat brain membrane immunoblot

Click on image to zoom

Species Reactivity

Human, Mouse, Rabbit, Rat

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: 75-221

Volume: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

LRP4 (extracellular)

Scientific Background

Low-density lipoprotein receptor-related protein 4 or LRP4 is encoded by the gene LRP4. And is a member of the low-density lipoprotein receptor-related protein family. Proteins in this family function in a wide range of physiological processes, including the regulation of lipid metabolism, protection against atherosclerosis, neurodevelopment. LRP4 may be involved in the negative regulation of the canonical Wnt signaling pathway. LRP4 is expressed in bone and several regions of the brain. Mutations in this gene are associated with Cenani-Lenz syndrome.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N207/27

Isotype

IgG2a

Applications

ELISA, ICC, IHC, WB

Host Species

Mouse

Gene Name

Lrp4 Kiaa0816

Molecular Weight

215 kDa

Immunogen

Fusion protein amino acids 26-350 (extracellular N-terminus) of mouse LRP4 (accession number Q8VI56) produced recombinantly in E. Coli

Immunogen Species

Mouse

Species Reactivity

Human, Mouse, Rabbit, Rat

Antibody Registry ID

AB_2139030

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Dilution Ranges

WB: 1:1000
IHC: 1:500

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

Low-density lipoprotein receptor-related protein 4 (LRP-4) (LDLR dan)

UniProt ID

Q8VI56

Shipping

Shipped on ice packs

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Anti-LRP4 (Extracellular) Antibody (N207/27)

SKU: 75-221

Product Details

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