Anti-Kv7.4/KCNQ4 K+ Channel Antibody (N43/6)

Name: Anti-Kv7.4/KCNQ4 K+ Channel Antibody
Brand: NeuroMab
SKU: 75-082
Price: 337.0 USD
Availability: InStock

Our mouse Kv7.4/KCNQ4 K+ channel monoclonal antibody from NeuroMab is produced in-house from clone N43/6. It detects bovine, human, mouse, and rat Kv7.4/KCNQ4 K+ channel and is purified by Protein A chromatography. Works in WB, IHC, ICC, IP, ELISA.

Mouse cochlea immunofluorescence. Labeling in crista ampullaris. Red = N43/6, Blue = Hoechst nuclear stain. Courtesy of Ms. Gesa Rickheit and Dr. Thomas Jentsch, Max-Delbrueck-Centrum fuer Molekulare Medizin, Berlin, Germany.

Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM (left lane) and COS-1 cells transiently transfected with KCNQ4 (middle lane) or Kv2.1 (right lane) plasmids and probed with pure N43/6 (left panel) or K89/41 TC supe (right panel).

Transfected cell immunofluorescence :COS-1 cell expressing KCNQ4 in a field of untransfected cells. Red = N43/6, Blue = Hoechst nuclear stain.

Mouse cochlea immunofluorescence. Labeling in outer hair cells in organ of Corti. Red = N43/6, Blue = Hoechst nuclear stain. Courtesy of Ms. Gesa Rickheit and Dr. Thomas Jentsch, Max-Delbrueck-Centrum fuer Molekulare Medizin, Berlin, Germany.

Adult mouse utricle sections. KV7.4 antibody (Cat. 75-082, 1:200, green) labeled calyces on two KV1.8-positive type I HCs (A.1), four KV1.8-positive type I HCs (A.2), and two KV1.8-negative type I HCs from a Kcna10–/– mouse (A.3). Image from publication. CC-BY-4.0 PMID: 39625061

Mouse cochlea immunofluorescence. Labeling in crista ampullaris. Red = N43/6, Blue = Hoechst nuclear stain. Courtesy of Ms. Gesa Rickheit and Dr. Thomas Jentsch, Max-Delbrueck-Centrum fuer Molekulare Medizin, Berlin, Germany.

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Species Reactivity

Bovine, Human, Mouse, Rat

Applications

ELISA, ICC, IHC, IP, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: 75-082

Volume: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Kv7.4/KCNQ4 K+ channel

Scientific Background

Potassium voltage-gated channel subfamily KQT member 4, Voltage-Gated Potassium Channel Subunit Kv7.4 or KCNQ4 is encoded by the gene KCNQ4. KCNQ4 is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. It is found in the outer hair cell of cochlea, brain, heart, and skeletal muscle. Diseases associated with KCNQ4 include types of deafness.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N43/6

Isotype

IgG1

Applications

ELISA, ICC, IHC, IP, WB

Host Species

Mouse

Gene Name

KCNQ4

Molecular Weight

77 kDa

Immunogen

Fusion protein amino acids 2-77 of human KCNQ4 (accession number P56696) produced recombinantly in E. Coli

Immunogen Species

Human

Species Reactivity

Bovine, Human, Mouse, Rat

Antibody Registry ID

AB_2131828

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.12

Dilution Ranges

WB: 1:500
IHC: 1:200
ICC: 1:200

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

Potassium voltage-gated channel subfamily KQT member 4 (KQT-like 4) (Potassium channel subunit alpha KvLQT4) (Voltage-gated potassium channel subunit Kv7.4)

UniProt ID

P56696

Shipping

Shipped on ice packs

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Anti-Kv7.4/KCNQ4 K+ Channel Antibody (N43/6)

SKU: 75-082

Product Details

Bulk Order Anti-Kv7.4/KCNQ4 K+ Channel Antibody

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