Anti-Kv1.6 K+ Channel Antibody (K19/36)

Name: Anti-Kv1.6 K+ Channel Antibody
Brand: NeuroMab
SKU: 75-012
Price: 337.0 USD
Availability: InStock

Our mouse Kv1.6 K+ channel monoclonal antibody from NeuroMab is produced in-house from clone K19/36. It detects human, mouse, and rat Kv1.6 K+ channel and is purified by Protein A chromatography. Works in WB, IHC, ICC, IP, ELISA.

Immunofluorescence staining transiently Kv1.6-transfected COS cells.

Immunoblot on adult rat brain membrane (RBM) and lysates from Kv1.6-transfected (COS+) and untransfected (COS-) COS cells.

Binding of serum samples 1, 3, 27, healthy control (HC) serum and a commercial antibody against the according Kv channels to transfected HEK293 cells. Cells were transfected with human Kv1.6 and stained with a Kv1.6 antibody (Cat. 75-012, 1:200; red). Binding of patient serum was visualized with anti-human-IgG-Cy3 antibody (green). Image from publication CC-BY-4.0. PMID:38665908

Immunofluorescence staining transiently Kv1.6-transfected COS cells.

Click on image to zoom

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, ICC, IHC, IP, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: 75-012

Volume: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Kv1.6 K+ channel

Scientific Background

Potassium voltage-gated channel subfamily A member 6 or Kv1.6 is encoded by the gene KCNA6. Kv1.6 is a potassium channel subunit is a member of the potassium channel, voltage-gated, shaker-related subfamily. Potassium channels form homotetrameric and heterotetrameric channels in the membrane with various other related proteins, including KCNA2, KCNA4, KCNA5, KCNA6, KCNA7. Kv1.6 is expressed in brain neurons as well as other cell types in the brain, in cardiac and smooth muscle tissue, ovary and testis.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

K19/36

Isotype

IgG3

Applications

ELISA, ICC, IHC, IP, WB

Host Species

Mouse

Gene Name

Kcna6

Molecular Weight

60 kDa

Immunogen

Synthetic peptide 507-525 (RERRSSYLPTPHRAYAEKR; cytoplasmic C-terminus) of rat Kv1.6 (accession number P17659)

Immunogen Species

Rat

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2234243

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4

Dilution Ranges

WB: 1:1000
IHC: 1:250
ICC: 1:500

Conjugate

Unconjugated

Specificity

Does not cross-react with other Kv1 channels

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

Potassium voltage-gated channel subfamily A member 6 (RCK2) (Voltage-gated potassium channel subunit Kv1.6) (Voltage-gated potassium channel subunit Kv2)

UniProt ID

P17659

Shipping

Shipped on ice packs

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Anti-Kv1.6 K+ Channel Antibody (K19/36)

SKU: 75-012

Product Details

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