Anti-Kv1.1 K+ Channel Antibody (K20/78)
Our mouse Kv1.1 K+ channel monoclonal antibody from NeuroMab is produced in-house from clone K20/78. It detects C. elegans, finch, human, mouse, rabbit, and rat Kv1.1 K+ channel and is purified by Protein A chromatography. KO validated. Works in WB, IHC, ICC, IP, ELISA.
Immunolabeling of postnatal 14 mouse hippocampus specifically labeling Kv1.1 (Cat. 75-007, 1:200, green) and Ankyrin G (red). DNA labeled with DAPI. Mice were transcardially perfused with ice-cold 4% paraformaldehyde in PBS, then brain removed and postfixed overnight. The 50 uM slices were floating sections, where antigen retrieval was performed with sodium citrate at 80 C for 30 minutes before immunolabeling. Images from J. Ramirez-Franco and O. El Far, Aix-Marseille Université and INSERM.
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C. elegans, Finch, Human, Mouse, Rabbit, Rat
ELISA, ICC, IHC, IP, WB
Mouse
SKU: 75-007
Ships: 1-2 business days
Product Details
Kv1.1 K+ channel
Potassium Channel Kv1.1 or Kcna1 is a member of the Shaker potassium channel family. Kv1.1 is expressed in the brain, CNS and in the kidney. Potassium channels form homotetrameric and heterotetrameric channels in the membrane with various other related proteins, including KCNA2, KCNA4, KCNA5, KCNA6, KCNA7. Kv1.1 is involved with the regulation of cellular functions and the control of neuronal excitability. Mutations in Kv1.1 are associated with Episodic ataxia type 1 and epilepsy.
Purified by Protein A chromatography
1 mg/mL
Monoclonal
K20/78
IgG1
ELISA, ICC, IHC, IP, WB
Mouse
Kcna1
85 kDa (major: mature glycosylation),65 kDa (minor: immature glycosylation)
Synthetic peptide amino acids 458-476 (cytoplasmic C-terminus) of rat Kv1.1 (EEDMNNSIAHYRQANIRTG; accession number P10499)
Rat
C. elegans, Finch, Human, Mouse, Rabbit, Rat
AB_10673165
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4
WB: 1:500
IHC: 1:250
ICC: 1:500
IHC: 1:250
ICC: 1:500
Unconjugated
No cross-reactivity reported
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
United States
24 months from date of receipt
Potassium voltage-gated channel subfamily A member 1 (RBKI) (RCK1) (Voltage-gated potassium channel subunit Kv1.1)
Shipped on ice packs

