Anti-Kir2.2 K+ Channel Antibody (N124B/38)

Name: Anti-Kir2.2 K+ Channel Antibody
Brand: NeuroMab
SKU: 75-203
Price: 337.0 USD
Availability: InStock

Our mouse Kir2.2 K+ channel monoclonal antibody from NeuroMab is produced in-house from clone N124B/38. It detects mouse and rat Kir2.2 K+ channel and is purified by Protein A chromatography. Works in WB, ICC, ELISA.

Adult rat brain membrane (RBM) and transfected cell immunoblot: extracts of RBM and COS cells transiently transfected with HA-tagged Kir2.2 or untagged Kv2.1 plasmids and probed with N124B/38 TC supe.

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Species Reactivity

Mouse, Rat

Applications

ELISA, ICC, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: 75-203

Volume: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

Kir2.2 K+ channel

Scientific Background

ATP-sensitive inward rectifier potassium channel 12or Kir2.2 is encoded by the gene KCNJ12. Kir2.2 is a member of the inward rectifier potassium ion channel family and plays a role controlling the resting membrane potential in muscle cells and neurons. Kir2.2 is an integral membrane protein that is expressed in heart, brain and in aortic endothelial cells. In brain, Kir2.2 is expressed throughout the forebrain and cerebellum. Diseases associated with KCNJ12 include Smith-Magenis Syndrome and Leber Congenital Amaurosis 16.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N124B/38

Isotype

IgG1

Applications

ELISA, ICC, WB

Host Species

Mouse

Gene Name

Kcnj12 Irk2

Molecular Weight

48 kDa

Immunogen

Synthetic peptide amino acids 390-410 (cytoplasmic C-terminus) of rat Kir2.2 (accession number P52188)

Immunogen Species

Rat

Species Reactivity

Mouse, Rat

Antibody Registry ID

AB_2130486

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.125

Conjugate

Unconjugated

Specificity

No cross-reactivity against Kir2.1 or Kir2.3

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

ATP-sensitive inward rectifier potassium channel 12 (Inward rectifier K(+) channel Kir2.2) (IRK-2) (Potassium channel, inwardly rectifying subfamily J member 12)

UniProt ID

P52188

Shipping

Shipped on ice packs

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Anti-Kir2.2 K+ Channel Antibody (N124B/38)

SKU: 75-203

Product Details

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