Anti-KCNU1/Slo3 pH-Sensitive Maxi-K+ Channel Antibody (N2/16)

Name: Anti-KCNU1/Slo3 pH-Sensitive Maxi-K+ Channel Antibody
Brand: NeuroMab
SKU: 75-056
Price: 337.0 USD
Availability: InStock

Our mouse KCNU1/Slo3 pH-sensitive maxi-K+ channel monoclonal antibody from NeuroMab is produced in-house from clone N2/16. It detects mouse and Xenopus KCNU1/Slo3 pH-sensitive maxi-K+ channel and is purified by Protein A chromatography. KO validated. Works in WB, ICC, IP, ELISA.

Immunoblot versus (E) membrane proteins from wild- type (wt), Slo3-eGFP and Slo3 knockout (Slo3-/-) mouse testes and (F) immunoprecipitation products from total testes proteins pulled down with N2/16 probed with N2/16. Data courtesy of Christopher Lingle (Washington University) and reproduced with permission from the Proceedings of the National Academy of Sciences of the United States of America (2011 Zeng et al., PMID 21427226).

Mouse sperm immunofluorescence staining.

Immunoblot versus (E) membrane proteins from wild- type (wt), Slo3-eGFP and Slo3 knockout (Slo3-/-) mouse testes and (F) immunoprecipitation products from total testes proteins pulled down with N2/16 probed with N2/16. Data courtesy of Christopher Lingle (Washington University) and reproduced with permission from the Proceedings of the National Academy of Sciences of the United States of America (2011 Zeng et al., PMID 21427226).

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Species Reactivity

Mouse, Xenopus

Applications

ELISA, ICC, IP, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

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Data Sheet

KO Validated

Trial Size

SKU: 75-056

Volume: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

KCNU1/Slo3 pH-sensitive maxi-K+ channel

Scientific Background

Potassium calcium-activated channel subfamily U member 1 is encoded by the gene KCNU1. KCNU1 is a member of the potassium channel family, calcium-activated (TC 1.A.1.3) subfamily, KCa5.1/KCNU1 sub-subfamily. KCNU1 is a testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates transport of K+. KCNU1 is expressed in the testis. Diseases associated with KCNU1 include Leukodystrophy, Hypomyelinating, 3 and Coffin-Siris Syndrome 1.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N2/16

Isotype

IgG1

Applications

ELISA, ICC, IP, WB

Host Species

Mouse

Gene Name

Kcnu1 Kcnma3 Ksper Slo3

Molecular Weight

115 kDa

Immunogen

Fusion protein amino acids 1052-1121 of mouse Slo3 (accession number O54982) produced recombinantly in E. Coli

Immunogen Species

Mouse

Species Reactivity

Mouse, Xenopus

Antibody Registry ID

AB_2131864

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.4

Dilution Ranges

WB: 1:500

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested on cells overexpressing target protein and confirmed to give the expected staining pattern.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

Potassium channel subfamily U member 1 (Calcium-activated potassium channel subunit alpha-3) (Calcium-activated potassium channel, subfamily M subunit alpha-3) (Pore-forming subunit of the sperm-specific alkalization activated K(+) current) (KSper) (Slowpoke homolog 3) (mSlo3) (pH-sensitive maxi potassium channel)

UniProt ID

O54982

Shipping

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Anti-KCNU1/Slo3 pH-Sensitive Maxi-K+ Channel Antibody (N2/16)

SKU: 75-056

Product Details

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