Human Mouse Rat
Fusion protein amino acids 27-306 (cytoplasmic N-terminus) of human TRPC1 (also known as Short transient receptor potential channel 1, Transient receptor potential cation channel subfamily C member 1, Transient receptor protein 1, TRP1, Trp-related protein 1 and Trrp1, accession number P48995)
Mouse: 99% identity (279/280 amino acids identical)
Rat: 99% identity (278/280 amino acids identical)
>50% identity with TRPC4Hybridoma kindly donated by Dr. Leonidas Tsiokas, University of Oklahoma Health Sciences Center (2003 Ma et al JBC, PMID 14530267).
This NeuroMab antibody is considered "Restricted" and is therefore not available for commercial re-distribution on a for-profit basis.
Does not cross-react with TRPC4 (based on KO validation results)
Short transient receptor potential channel 1 (TrpC1) (Transient receptor protein 1) (TRP-1)
TC Supernatant: AB_10999751
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody has been knockout-validated in mouse brain (by Western blot and/or immunohistochemistry).
This antibody recognizes a single immunoreactive band of expected molecularweight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
Citations and References
- Ludlow MJ1, Gaunt HJ1, Rubaiy HN1, Musialowski KE1, Blythe NM1, Vasudev NS1, Muraki K2, Beech DJ3.. (2017), '(-)-Englerin A-evoked Cytotoxicity Is Mediated by Na+ Influx and Counteracted by Na+/K+-ATPase..' J Biol Chem. 10.1074/jbc.M116.755678.
- Hong C1, Seo H2, Kwak M1, Jeon J2, Jang J2, Jeong EM3, Myeong J1, Hwang YJ4, Ha K1, Kang MJ5, Lee KP6, Yi EC5, Kim IG3, Jeon JH1, Ryu H7, So I8.. (2015), 'Increased TRPC5 glutathionylation contributes to striatal neuron loss in Huntington's disease..' Brain. . 10.1093/brain/awv188.