TrkA-Fc Chimera, Human, Purified Recombinant Protein

Name: TrkA-Fc Chimera, Human, Purified Recombinant Protein
Brand: Biosensis
SKU: PE-1248-100
Price: 377.0 USD
Availability: InStock

Tyrosine Kinase Receptor A (TrkA)-Fc Chimera, purified human recombinant protein, suitable to block.

Gel analysis of TrkA-Fc Chimera.

Lane 1: MW marker
Lane 2: TrkA-Fc Chimera (20 µg), non-reducing
Lane 3: TrkA-Fc Chimera (20 µg), reducing condition

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Applications

Block

Host Species

HEK293

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Data Sheet

SKU: PE-1248-100

Volume/Size: 100 µg

Variant

Price:

$377.00

Quantity:

Product Details

Target

Tyrosine Kinase Receptor A (TrkA)

Scientific Background

TrkA is a member of the neurotrophic tyrosine kinase receptor family. It is a membrane-bound receptor that upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. TrkA is required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). TrkA leads to cell differentiations and may play a role in specifying sensory neuron subtypes. It has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. SUBCELLULAR LOCATION: TrkA is a heavily glycosylated transmembrane protein and contains 13 potential N-linked glycosylation sites. The TrkA-Fc chimera has N-linked and may have O-linked oligosaccharides.

Format

Protein G purified

Applications

Block

Host Species

HEK293

Protein Sequence

A DNA sequence encoding the signal peptide and extracellular domain of human TrkA (amino acids 1- 413) was fused to the Fc region of human IgG1 (amino acids 104-330). The chimeric protein was expressed in modified human 293 cells.

Storage

Spin vial briefly before opening. Reconstitute with sterile PBS, pH 7.4 to give a concentration of 0.5 mg/mL.Lyophilized products should be stored at 2 to 8°C. Following reconstitution, short-term storage at 2-8°C is recommended and longer-term storage of aliquots at -18 to -20°C. Repeated freeze thawing is not recommended.

Physical State

Liquid

Production Notes

>95% purity, as determined by SDS-PAGE.

Usage Statement

For research use only.

Country of Origin

United States

Expiration

12 months after date of receipt (unopened vial).

Synonyms

Tropomyosin-related kinase receptor; High affinity nerve growth factor receptor; Neurotrophic tyrosine kinase receptor type 1; TRK1 transforming tyrosine kinase protein; p140-TrkA; Trk-A; NTRK1; TRK

UniProt ID

P04629

Shipping

25°C (ambient)

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TrkA-Fc Chimera, Human, Purified Recombinant Protein

SKU: PE-1248-100

Product Details

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