Human Mouse Rat
SynCAM4 cell adhesion molecule, Immunoglobulin Superfamily, Member 4C (IGSF4C), or Nectin-Like Protein 4 (NECL4) is encoded by the gene CADM4 and is a member of the Immunoglobulin-like Cell Adhesion Molecules family. SynCam4 is a cell adhesion molecule involved in many cell processes including the mediation of cell-cell adhesion and assembly, neuronal migration axon growth and differentiation. SynCAM1 is expressed in several tissue types including brain, kidney and liver. Diseases associated with with this gene include Small Intestine Adenocarcinoma.
Fusion protein amino acids 1-321 (signal peptide and extracellular N-terminus) of mouse SynCAM4 (also known as Cell adhesion molecule 4, Immunoglobulin superfamily member 4C, Nectinlike protein 4, TSLC1-like protein 2, Cadm4, Igsf4c, Necl4 and Tsll2, accession number Q8R464); Rat: 99% identity (319/321 amino acids identical); Human: 98% identity (316/321 amino acids identical)
~30-40% identity with SynCAM1, SynCAM2 and SynCAM3
Does not cross-react with other SynCAMs (based on KO validation results)
Cadm4 Igsf4c Necl4 Tsll2
TC Supernatant: AB_10673109
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody has been knockout-validated in mouse brain (by Western blot and/or immunohistochemistry).
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.