Human Mouse Rat
Synaptotagmins are a family of calcium sensing, membrane trafficking proteins. 17 different synaptotagmins have been identified in mammals. Synaptotagmin 3 is predominantly expressed in postsynaptic endocytic zones of neurons and has recently been shown to internalize AMPA receptors to depress synaptic strength and promote forgetting (Awasthi A. et al., 2019).
Fusion protein amino acids 442-533 (cytoplasmic C2B domain) of mouse Synaptotagmin-3 (also known as Syt3, Synaptotagmin III and SytIII, accession number O35681)
Human: 100% identity (92/92 amino acids identical)
Rat: 98% identity (91/92 amino acids identical)
>70% identity with Synaptotagmin-9, Synaptotagmin-10 and Synaptotagmin-6
Does not cross-react with other Synaptotagmins
Synaptotagmin-3 (Synaptotagmin III) (SytIII)
TC Supernatant: AB_11001828
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe lysate from COS cells overexpressing target.
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.