ICC IHC WB
Rad And Gem-Like GTP-Binding Protein 2 or GTP-binding protein REM 2 is encoded by the gene Rem2 and is a member of the small GTPase superfamily and the Rad/Rem/Rem2/Gem/Kir (RGK) subfamily. REM2 binds GTP and plays roles in diverse processes including modulation of calcium channel currents, (Ref Zheng JQ et al. 2007), mediation of excitatory and inhibitory synapse development (Ref: Paradis et al. 2007). REM2 is expressed in brain and kidney. Diseases associated with this gene include Long Qt Syndrome.
Fusion protein amino acids 1-341 (full-length) of rat Rem2 (also known as Rad and Gem-like-GTP-binding protein 2, accession number Q9WTY2)
Mouse: 97% identity (332/341 amino acids identical)
Human: 92% identity (315/341 amino acids identical)
<50% identity with Rad, Gem and Rem1
Does not cross-react with Rad, Gem or Rem1
GTP-binding protein REM 2 (Rad and Gem-like GTP-binding protein 2)
TC Supernatant: AB_11000051
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe lysate from COS cells overexpressing target.
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
45 kDa (and larger due to oligomerization)
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.