Human Mouse Rat
Inositol polyphosphate 5-phosphatase B is encoded by the gene INPP5B. INPP5B is a member of the inositol 1,4,5-triphosphate 5-phosphatase family. INPP5B functions in the regulation of calcium signaling by inactivating inositol phosphates. INPP5B is expressed highest in the urinary bladder. Diseases associated with INPP5B include dent disease 2, lowe oculocerebrorenal syndrome, charcot-marie-tooth disease type 4j, dent disease 1, and frontotemporal dementia and/or amyotrophic lateral sclerosis 2.
Fusion protein amino acids 1-901 (full-length) of human OCRL (also known as OCRL1, Lowe oculocerebrorenal syndrome protein, Inositol polyphosphate 5-phosphatase and INPP5f, accession number Q01968); Rat: 93% identity (845/904 amino acids identical); Mouse: 91% identity (824/901 amino acids identical); Greater than 50% identity with INPP5b
Cross-reacts with INPP5b
TC Supernatant: AB_10673580
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe lysate from COS cells overexpressing target.
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.