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Products: Primary Antibodies

Anti-OCRL/INPP5b Antibody (N166A/26)

NeuroMab Logo from NeuroMab

 Datasheet

PRODUCT OPTIONS

Brand Catalog # Option Volume Concentration Price
Brand
NeuroMab Logo
Catalog #
75-215
Option
Purified
Volume
100 µL
Concentration
1 mg/mL
Price
$275.00
Brand
NeuroMab Logo
Catalog #
73-215
Option
TC Supernatant
Volume
5 mL
Concentration
Lot dependent
Price
$275.00

Validation Images


Product Details

Antibody Type:

Monoclonal

Host Species:

Mouse

Antibody Isotype:

IgG1

Species Reactivity:

Human Mouse Rat

Applications:
WB Western Blot
IHC Immunohistochemistry
ICC Immunocytochemistry
IP Immunoprecipitation
AT Array Tomography
EM Electron Microscopy
CHIP Chromatin Immunoprecipitation
DB Dot Blot

ICC WB

Target Description:

Inositol polyphosphate 5-phosphatase B is encoded by the gene INPP5B. INPP5B is a member of the inositol 1,4,5-triphosphate 5-phosphatase family. INPP5B functions in the regulation of calcium signaling by inactivating inositol phosphates. INPP5B is expressed highest in the urinary bladder. Diseases associated with INPP5B include dent disease 2, lowe oculocerebrorenal syndrome, charcot-marie-tooth disease type 4j, dent disease 1, and frontotemporal dementia and/or amyotrophic lateral sclerosis 2.

Immunogen:

Fusion protein amino acids 1-901 (full-length) of human OCRL (also known as OCRL1, Lowe oculocerebrorenal syndrome protein, Inositol polyphosphate 5-phosphatase and INPP5f, accession number Q01968); Rat: 93% identity (845/904 amino acids identical); Mouse: 91% identity (824/901 amino acids identical); Greater than 50% identity with INPP5b

Cross Reactivity:

Cross-reacts with INPP5b

Protein Name(s):

OCRL/INPP5b

Gene Name(s):

INPP5B OCRL2

Antibody Registry ID:

Purified: AB_2156491
TC Supernatant: AB_10673580


Antibody Validation and Application Notes


This antibody has been validated using the following assays:
Western Blot:

This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe lysate from COS cells overexpressing target.

This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Immunocytochemistry:

This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.

Molecular Weight:

100 kDa


Quality Control


The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.

Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.