Fusion protein amino acids 116-206 (C-terminus) of human Mad3 (also known as Max-interacting transcriptional repressor, Max-associated protein 3, MAX dimerization protein 3, Myx and Mxd3, accession number Q9BW11)
Mouse: 82% identity (75/91 amino acids identical)
Rat: 78% identity (71/91 amino acids identical)
~50% identity with Mxi1
Does not cross-react with Mxi1
Max dimerization protein 3 (Max dimerizer 3) (Class C basic helix-loop-helix protein 13) (bHLHc13) (Max-associated protein 3) (Max-interacting transcriptional repressor MAD3) (Myx)
MXD3 BHLHC13 MAD3
TC Supernatant: AB_11030250
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe lysate from COS cells overexpressing target.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.
Citations and References
- Barisone GA1, Satake N2, Lewis C3, Duong C3, Chen C3, Lam KS4, Nolta J5, Dίaz E6.. (2015), 'Loss of MXD3 induces apoptosis of Reh human precursor B acute lymphoblastic leukemia cells..' Blood Cells Mol Dis. . 10.1016/j.bcmd.2014.12.002.
- Satake N1, Duong C, Chen C, Barisone GA, Diaz E, Tuscano J, Rocke DM, Nolta J, Nitin N.. (2014), 'Targeted therapy with MXD3 siRNA, anti-CD22 antibody and nanoparticles for precursor B-cell acute lymphoblastic leukaemia..' Br J Haematol.. 10.1111/bjh.13066.
- Ngo T, Barisone GA, Lam KS, Dίaz E1.. (2014), 'MXD3 regulation of DAOY cell proliferation dictated by time course of activation..' BMC Cell Biol.. 10.1186/1471-2121-15-30.
- Carneiro K1, Donnet C, Rejtar T, Karger BL, Barisone GA, Díaz E, Kortagere S, Lemire JM, Levin M.. (2011), 'Histone deacetylase activity is necessary for left-right patterning during vertebrate development..' BMC Dev Biol.. 10.1186/1471-213X-11-29.