Kir2.1 (KCNJ2) is a member of the inward rectifier potassium ion channel family which also includes Kir2.2 and Kir2.3. Kir2.1 is expressed in the membranes of many tissues, including heart, skeletal muscle, kidney and diffusely distributed throughout the brain. Kir2.1 has a role in cardiac excitability and has been shown to have interactions with CLG4, Interleukin 16 and TRAK2. Defects in Kir2.1 are involved with the diseases long QT syndrome type 7 (also known as andersen-Tawil syndrome), short QT syndrome 3, and Familial Atrial Fibrillation 9.
Synthetic peptide amino acids 390-411 (cytoplasmic C-terminus) of mouse Kir2.1 also known as Inward rectifier potassium channel 2 or subfamily J member 2, Kcnj2 and Irk1, accession number P35561); Rat: 100% identity (22/22 amino acids identical); Human: 90% identity (20/22 amino acids identical)
No cross-reactivity against Kir2.2 or Kir2.3
Kir2.1 K+ channel
TC Supernatant: AB_11001668
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe lysate from COS cells overexpressing target.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it shows the expected staining pattern when used to stain COS cells overexpressing target.