Human Mouse Rat
ICC IHC WB
Glutamate receptor ionotropic, NMDA 2C, Nmethyl D-aspartate receptor subtype 2C, or GluN2C/NR2C is encoded by the gene GRIN2C. GluN2C is a subunit of the N-methyl-D-aspartate (NMDA) receptor, which is a subtype of channel forming ionotropic glutamate receptor which is permeable to cations including calcium, potassium and sodium. GluN2C is found in the central nervous system and the cerebellum. GluN2C is thought to have an important role in physiological processes such as learning, memory, and synaptic development. Diseases associated with this gene include Alzheimer disease, Parkinson’s disease and Schizophrenia.
Fusion protein amino acids 836-1233 (cytoplasmic C-terminus) of rat GluN2C (also known as Glutamate receptor ionotropic NMDA 2C, Glutamate [NMDA] receptor subunit epsilon-3, Nmethyl D-aspartate receptor subtype 2C, NMDAR2C, NR2C and Grin2c, accession number Q00961)
Mouse: 93% identity (372/400 amino acids identical)
Human: 72% identity (293/405 amino acids identical)
30% identity with GluN2D/NR2D and other GluN/NMDA receptors
Glutamate receptor ionotropic, NMDA 2C (GluN2C) (Glutamate [NMDA] receptor subunit epsilon-3) (N-methyl D-aspartate receptor subtype 2C) (NMDAR2C) (NR2C)
TC Supernatant: AB_2491108
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody has been knockout-validated in mouse brain (by Western blot and/or immunohistochemistry).
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.