ICC IHC WB
Gamma-aminobutyric acid receptor subunit alpha-2 or GABA AR-Alpha2 is encoded by the gene GABRA2. GABAA receptors are members of the Cys-loop family of ligand-gated ion channels. GABA AR alpha 5 is a subunit of the pentameric GABA receptors where GABA is the major inhibitory neurotransmitter in the vertebrate brain and mediates neuronal inhibition by binding to the GABA receptor and opening an integral chloride channel. GABA AR-Alpha2 is primarily expressed in brain at the cell junction, synapse,and the postsynaptic cell membrane. Diseases associated with GABRA2 include Alcohol Dependence and Alcohol Use Disorder.
Fusion protein amino acids 350-385 (cytoplasmic C-terminus) of rat GABA-A-R-Alpha2 (also known as Gamma-aminobutyric acid receptor subunit alpha-2, GABA(A) receptor subunit alpha-2 and Gabra2, accession number P23576)
Mouse: 100% identity (36/36 amino acids identical)
Human: 97% identity (35/36 amino acids identical)
50% identity with GABA-A-R-Alpha1
Does not cross-react with GABA-A-R-Alpha1
Gamma-aminobutyric acid receptor subunit alpha-2 (GABA(A) receptor subunit alpha-2)
TC Supernatant: AB_2336904
Antibody Validation and Application Notes
This antibody has been validated using the following assays:
This antibody has been knockout-validated in mouse brain (by Western blot and/or immunohistochemistry).
This antibody recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.
This antibody shows the expected staining pattern when used to stain COS cells overexpressing target.
The following quality control assay is performed on each new lot of this antibody to ensure it meets designated performance requirements.
Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.