Transfected cell immunoblot: extracts of COS cells transiently transfected with V5/His-tagged THAP1 or untagged Kv2.1 plasmid and probed with N325B/65 TC supe (left) and mouse anti-V5 (right).
THAP domain-containing protein 1
THAP (Thanatos-associated protein) domain-containing, apoptosis-associated protein 1)domain-containing protein 1, Nuclear Proapoptotic Factor or Dystonia 6, Torsion (Autosomal Dominant) is encoded by the gene THAP1. THAP1 is a DNA-binding transcription regulator involved in endothelial cell proliferation, G1/S cell-cycle progression and is thought to play a role in apoptosis. Thap1 is expressed in many tissues including heart, skeletal muscle, kidney, liver, brain and placenta. Diseases associated with this gene include Dystonia.
Fusion protein amino acids 1-213 (full-length) of human THAP1 (also known as THAP domain containing
protein 1, accession number Q9NVV9)
Mouse: 92% identity (197/213 amino acids identical)
Rat: 92% identity (196/213 amino acids identical)
Less than 40% identity with THAP2, THAP3 and other THAP proteins
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.