Immunoblot versus low-speed pellet samples from wild-type (WT) and Stargazer mutant (STG) mice and probed with N245/1 TC supe. Data courtesy of Susumu Tomita, Yale University.
Voltage-dependent calcium channel gamma-2 subunit, TARPGamma2 or Stargazin is encoded by the gene CACNG2 and is the transmembrane gamma subunit of the L-type calcium channel. Stargazin is in involved in regulation and trafficking of the ligand gated ion channel AMPA receptors. It is thought to play a role in learning and memory. Diseases associated with this gene include forms of deafness, Mental Retardation and childhood absnce epilepsy.
Fusion protein amino acids 203-323 (cytoplasmic C-terminus) of rat TARPGamma2 (also known as Voltage-dependent calcium channel gamma-2 subunit, Neuronal voltage-gated calcium channel gamma-2 subunit, Stargazin and Stg, accession number Q71RJ2); Mouse: 100% identity (121/121 amino acids identical); Human: 96% identity (117/121 amino acids identical)
Greater than 50% identity with TARPGamma3, TARPGamma4 and TARPGamma8
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