Anti-SynCAM4 Antibody (N244/5)

Name: Anti-SynCAM4 Antibody
Brand: NeuroMab
SKU: 75-247
Price: 295.0 USD
Availability: InStock

from NeuroMab Datasheet KO Validated

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Clonality

Monoclonal

Applications

ICC, WB

Host Species

Mouse

Gene Name

Cadm4 Igsf4c Necl4 Tsll2

Molecular Weight

43 kDa

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Immunoblot versus adult rat brain membranes (RBM) and adult mouse brain membranes from wild-type (WT) and SynCAM4 knockout (KO) mice and probed with N244/5 (left) and K89/41 (right) TC supe. Samples courtesy of Matt Rasband, Baylor College of Medicine.

Adult rat sciatic nerve immunofluorescence staining: paranodes labeled with N244/5 (red) surround nodes of Ranvier labeled with Beta-IV spectrin (green) (image on right is cross-section of a similar image of left). Images courtesy of Matt Rasband (Baylor College of Medicine).

Product Details

Target

SynCAM4

Target Description

SynCAM4 cell adhesion molecule, Immunoglobulin Superfamily, Member 4C (IGSF4C), or Nectin-Like Protein 4 (NECL4) is encoded by the gene CADM4 and is a member of the Immunoglobulin-like Cell Adhesion Molecules family. SynCam4 is a cell adhesion molecule involved in many cell processes including the mediation of cell-cell adhesion and assembly, neuronal migration axon growth and differentiation. SynCAM1 is expressed in several tissue types including brain, kidney and liver. Diseases associated with with this gene include Small Intestine Adenocarcinoma.

Format

Purified

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N244/5

Isotype

IgG1

Applications

ICC, WB

Host Species

Mouse

Gene Name

Cadm4 Igsf4c Necl4 Tsll2

Molecular Weight

43 kDa

Antigen

Fusion protein amino acids 1-321 (signal peptide and extracellular N-terminus) of mouse SynCAM4 (also known as Cell adhesion molecule 4, Immunoglobulin superfamily member 4C, Nectinlike protein 4, TSLC1-like protein 2, Cadm4, Igsf4c, Necl4 and Tsll2, accession number Q8R464); Rat: 99% identity (319/321 amino acids identical); Human: 98% identity (316/321 amino acids identical) ~30-40% identity with SynCAM1, SynCAM2 and SynCAM3

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_10676101

Storage

Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Buffer

10mM Tris, 50mM Sodium Chloride, 0.065 % Sodium Azide pH 7.4

Conjugate

Unconjugated

Specificity

Does not cross-react with other SynCAMs (based on KO validation results)

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from opening

Synonyms

Cell adhesion molecule 4 (Immunoglobulin superfamily member 4C) (IgSF4C) (Nectin-like protein 4) (NECL-4) (TSLC1-like protein 2)

UniProt Details

UniProt (Human): Q8NFZ8
UniProt (Immunogen Species): Q8R464

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Anti-SynCAM4 Antibody (N244/5)

Anti-SynCAM4 Antibody
SKU: 75-247

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Anti-SynCAM4 Antibody (N244/5)

Anti-SynCAM4 Antibody SKU: 75-247

Product Details

Anti-SynCAM4 Antibody
SKU: 75-247