Adult rat sciatic nerve immunofluorescence staining: paranodes labeled with N244/5 (red) surround nodes of Ranvier labeled with Beta-IV spectrin (green) (image on right is cross-section of a similar image of left). Images courtesy of Matt Rasband (Baylor College of Medicine).
SynCAM4 cell adhesion molecule, Immunoglobulin Superfamily, Member 4C (IGSF4C), or Nectin-Like Protein 4 (NECL4) is encoded by the gene CADM4 and is a member of the Immunoglobulin-like Cell Adhesion Molecules family. SynCam4 is a cell adhesion molecule involved in many cell processes including the mediation of cell-cell adhesion and assembly, neuronal migration axon growth and differentiation. SynCAM1 is expressed in several tissue types including brain, kidney and liver. Diseases associated with with this gene include Small Intestine Adenocarcinoma.
Cadm4 Igsf4c Necl4 Tsll2
Fusion protein amino acids 1-321 (signal peptide and extracellular N-terminus) of mouse SynCAM4 (also known as Cell adhesion molecule 4, Immunoglobulin superfamily member 4C, Nectinlike protein 4, TSLC1-like protein 2, Cadm4, Igsf4c, Necl4 and Tsll2, accession number Q8R464); Rat: 99% identity (319/321 amino acids identical); Human: 98% identity (316/321 amino acids identical)
~30-40% identity with SynCAM1, SynCAM2 and SynCAM3
Human, Mouse, Rat
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