Anti-SNAT1 Antibody (N104/37)

Name: Anti-SNAT1 Antibody
Brand: NeuroMab
SKU: 75-155
Price: 337.0 USD
Availability: InStock

Our mouse SNAT1 monoclonal antibody from NeuroMab is produced in-house from clone N104/37. It detects human, mouse, and rat SNAT1 and is purified by Protein A chromatography. Works in WB, ICC, ELISA.

Adult rat brain membrane (RBM) immunoblot.

Surface expression of SNAT1 and SNAT2 in HCC1806 cells starved of amino acids over 24 h. Image from publication CC-BY-4.0. PMID:36210829

Adult rat brain membrane (RBM) immunoblot.

Click on image to zoom

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, ICC, WB

Host Species

Mouse

Conjugates and Formulations

490

550

594

650

Biotin

Carrier-Free

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Data Sheet

SKU: 75-155

Volume: 100 µL

Variant

Price:

$337.00

Quantity:

Ships: 1-2 business days

Product Details

Target

SNAT1

Scientific Background

Sodium-coupled neutral amino acid transporter 1 (SNAT1) or Solute Carrier Family 38 Member 1 is encoded by the gene Slc38a1 and belongs to the amino acid/polyamine transporter 2 family. SNAT1 acts as a sodium-dependent transporter of glutamine which serves as a precursor for the synaptic transmitter, glutamate. SNAT1 is expressed in brain, specifically at glutamatergic and GABAergic neurons, and also expressed in placenta, heart, lung, skeletal muscle, spleen, stomach and testis. Diseases associated with this gene include Klatskin's Tumor.

Format

Purified by Protein A chromatography

Concentration

1 mg/mL

Clonality

Monoclonal

Clone

N104/37

Isotype

IgG1

Applications

ELISA, ICC, WB

Host Species

Mouse

Gene Name

Slc38a1 Ata1 Glnt Sa2 Sat1 Snat1

Molecular Weight

50 kDa

Immunogen

Fusion protein amino acids 1-63 (cytoplasmic N-terminus) of rat SNAT1 (accession number Q9JM15) produced recombinantly in E. Coli

Immunogen Species

Rat

Species Reactivity

Human, Mouse, Rat

Antibody Registry ID

AB_2254872

Storage

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

Physical State

Liquid

Production Notes

Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.

Buffer

10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.81

Conjugate

Unconjugated

Specificity

No cross-reactivity reported

Quality Control

Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.

Usage Statement

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Country of Origin

United States

Expiration

24 months from date of receipt

Synonyms

Ata1; Sodium-coupled neutral amino acid transporter 1; Sat1; Amino acid transporter A1; rATA1; N-system amino acid transporter 2; Glutamine transporter; amino acid transporter system A1; Solute carrier family 38 member 1; System A amino acid transporter 1; System A transporter 2; System N amino acid transporter 1

UniProt ID

Q9JM15
UniProt Summary: Symporter that cotransports short-chain neutral amino acids and sodium ions from the extracellular to the intracellular side of the cell membrane. The transport is elctrogenic, pH dependent and driven by the Na(+) electrochemical gradient. Participates in the astroglia-derived glutamine transport into GABAergic interneurons for neurotransmitter GABA de novo synthesis. May also contributes to amino acid transport in placental trophoblast. Regulates synaptic plasticity.

NCBI Gene ID

170567

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Anti-SNAT1 Antibody (N104/37)

SKU: 75-155

Product Details

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