Zinc finger protein 746, Parkin-Interacting Substrate or PARIS/ZNF746 is encoded by the gene ZNF746. PARIS is a transcription repressor that binds to a consensus sequence on promoters and represses the expression of a transcriptional coactivator, PGC-1-alpha (PPARGC1A). This protein plays a role in regulation of neuron death. PARIS is found in the cytoplasm and nucleus
ICC, IHC, WB
Fusion protein amino acids 1-322 (N-terminus) of human ZNF746 (also known as Zinc finger protein 746 and Zfp746, accession number Q6NUN9); Mouse: 96% identity (312/323 amino acids identical); Greater than 50% identity with ZNF783, ZNF282 and ZNF398
Human, Mouse, Rat
Store at ≤ -20 C for long term storage. For short term storage, store at 2-8 C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Does not cross-react with ZNF783 or ZNF398
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
24 months from opening
Zinc finger protein 746 (Parkin-interacting substrate) (PARIS)