Anti-PARIS/ZNF746 Antibody (N196/16)
Our Anti-PARIS/ZNF746 mouse monoclonal primary antibody from NeuroMab is produced in-house from hybridoma clone N196/16. It detects human, mouse, and rat PARIS/ZNF746, and is purified by Protein A chromatography. It is great for use in IHC, ICC, WB.
SKU: 75-195
Product Details
PARIS/ZNF746
Zinc finger protein 746, Parkin-Interacting Substrate or PARIS/ZNF746 is encoded by the gene ZNF746. PARIS is a transcription repressor that binds to a consensus sequence on promoters and represses the expression of a transcriptional coactivator, PGC-1-alpha (PPARGC1A). This protein plays a role in regulation of neuron death. PARIS is found in the cytoplasm and nucleus
Purified by Protein A chromatography
1 mg/mL
Monoclonal
N196/16
IgG1
ICC, IHC, WB
Mouse
ZNF746 PARIS
60-70 kDa
Fusion protein amino acids 1-322 (N-terminus) of human ZNF746 (accession number Q6NUN9) produced recombinantly in E. Coli
Human, Mouse, Rat
AB_10674714
Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.
Liquid
Produced by in vitro bioreactor culture of hybridoma line followed by Protein A affinity chromatography. Purified mAbs are >90% specific antibody.
10 mM Tris, 50 mM Sodium Chloride, 0.065% Sodium Azide pH 7.123
Unconjugated
Does not cross-react with ZNF783 or ZNF398
Each new lot of antibody is quality control tested by western blot on rat whole brain lysate and confirmed to stain the expected molecular weight band.
These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.
United States
24 months from date of receipt
Shipped on ice packs
Zinc finger protein 746 (Parkin-interacting substrate) (PARIS)
UniProt (Human): Q6NUN9
UniProt (Immunogen Species): Q6NUN9
UniProt (Immunogen Species): Q6NUN9
- Liu Z, Liu Y, Gao R, Li H, Dunn T, Wu P, Smith RG, Sarkar PS, Fang X. (2014), 'Ethanol suppresses PGC-1α expression by interfering with the cAMP-CREB pathway in neuronal cells..' PLoS One. 10.1371/journal.pone.0104247.
- Silva DF, Selfridge JE, Lu J, E L, Roy N, Hutfles L, Burns JM, Michaelis EK, Yan S, Cardoso SM, Swerdlow RH. (2013), 'Bioenergetic flux, mitochondrial mass and mitochondrial morphology dynamics in AD and MCI cybrid cell lines..' Human Molecular Genetics. 10.1093/hmg/ddt247.
- Kang HC, Lee YI, Shin JH, Andrabi SA, Chi Z, Gagné JP, Lee Y, Ko HS, Lee BD, Poirier GG, Dawson VL, Dawson TM. (2011), 'Iduna is a poly(ADP-ribose) (PAR)-dependent E3 ubiquitin ligase that regulates DNA damage..' Proceedings of the National Academy of Science of the United States of America. 10.1073/pnas.1108799108.