Immunofluorescence staining of a node of Ranvier in adult rat sciatic nerve with N343/26 (green) and bIV-spectrin rabbit polyclonal (red). Image courtesy of Kae-Jiun Chang and Matt Rasband (Baylor College of Medicine.
Neuronal Cell Adhesion Molecule is encoded by the gene NRCAM. NRCAM is a member of the immunoglobulin superfamily, L1/neurofascin/NgCAM family. NRCAM is an ankyrin-binding protein that is involved in neuron-neuron adhesion and promotes directional signaling during axonal cone growth. NRCAM also may play a role in cell-cell communication via signalling from its intracellular domain to the actin cytoskeleton during directional cell migration. NRCAM is expressed in the brain. Diseases associated with NRCAM include Masa Syndrome and Autism.
Fusion protein amino acids 30-845 (extracellular domain) of mouse NrCAM (also known as Neuronal cell adhesion molecule, Ankyrin-binding cell adhesion molecule, Neuronal surface protein Bravo, NgCAM-related cell adhesion molecule and KIAA0343, accession number Q810U4)
Rat: 96% identity (795/822 amino acids identical)
Human: 91% identity (753/822 amino acids identical)
~50% identity with Neurofascin
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